Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. (2017). Correlation between Vitamin D Deficiency and Depression. test, 69(8), 3134-3143. doi: 10.12816/0042865
Afnan Hedian Alsofyani; Abeer Mohammed M Alharbi; Arwa Bader N Alanazi; Khaled Abdul Aziz Alasous; Rawan Ahmad Ageeli; Amirah Abduallah M ALZahrani; Moatez Khalaf Almofarreh; Reham Awdah Albalwi; Samirah Nasser A Majrshi; Muhannad Fahad W Alsahli; Ayat Essam Shaban; Ghaida Mohammad Ahmad. "Correlation between Vitamin D Deficiency and Depression". test, 69, 8, 2017, 3134-3143. doi: 10.12816/0042865
Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. (2017). 'Correlation between Vitamin D Deficiency and Depression', test, 69(8), pp. 3134-3143. doi: 10.12816/0042865
Alsofyani, A., Alharbi, A., Alanazi, A., Alasous, K., Ageeli, R., ALZahrani, A., Almofarreh, M., Albalwi, R., Majrshi, S., Alsahli, M., Shaban, A., Ahmad, G. Correlation between Vitamin D Deficiency and Depression. test, 2017; 69(8): 3134-3143. doi: 10.12816/0042865

Correlation between Vitamin D Deficiency and Depression

The Egyptian Journal of Hospital Medicine
Article 28, Volume 69, Issue 8, October 2017, Pages 3134-3143    PDF (459.82 K)
Document Type: Original Article
DOI: 10.12816/0042865
Authors
Afnan Hedian Alsofyani1; Abeer Mohammed M Alharbi2; Arwa Bader N Alanazi3; Khaled Abdul Aziz Alasous4; Rawan Ahmad Ageeli5; Amirah Abduallah M ALZahrani6; Moatez Khalaf Almofarreh7; Reham Awdah Albalwi8; Samirah Nasser A Majrshi9; Muhannad Fahad W Alsahli10; Ayat Essam Shaban11; Ghaida Mohammad Ahmad12
1Taif University
2Alfaisal University
3Northern Border University
4Sattam Bin Abdulaziz University
5Jazan University
6King Abdullaziz Hospital
7Aljouf University
8Tabuk University
9Primary Health Care Al-Jumum- Makkah
10Al Imam Abdulrahman Al Faisal Hospital in Riyadh
11Al Nahda Primary Health Care Center, Jeddah
12East Jeddah Hospital
Abstract
Aim of the Study: To conduct a systematic review and meta-analysis of prospective cohort studies of the association of vitamin D deficiency with onset of depression in non- depressed individuals.
Methods: A systematic review of the electronically searched publications of the scientific literature. We searched the Cochrane Hepato Biliary Group Controlled Trials Register, Cochrane Central Register of Controlled Trials in The Cochrane Library, MEDLINE (1946 to 2017), EMBASE (1974 to 2017), and Science Citation Index Expanded (1900 to 2017).  Initially all randomized clinical trials which studied the correlation of Vitamin D with depression were included, articles were then selectively screened according to the eligibility criteria. Results: the search yielded 11 studies, A meta-analysis of all studies without flaws demonstrated a statistically significant improvement in depression with Vitamin D supplements (+0.72 CI +0.28, +1.31). Nevertheless, studies with biological flaws were mainly inconclusive
Conclusion: Our analyses are consistent with the hypothesis that Vitamin D supplementation (≥800 I.U. daily) was supported in the management of depression.
 
Keywords
depression; biological plausibility; Meta-Analysis; systematic review; 25OHD; Vitamin D supplementation
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