Circulating Maternal Serum Cell Free Fetal DNA Levels for prediction of Preeclampsia | ||
| Evidence Based Women's Health Journal | ||
| Article 10, Volume 12, Issue 1, February 2022, Pages 77-85 PDF (1.48 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2020.28158.1093 | ||
| Authors | ||
| Mohammad Soroura* 1; Maged El Shorbagy2; mohamed SHAWKY2; TAMER Borg2; Karim Wahba2; Ahmed Reyad2 | ||
| 1Obstetrics and gynecology faculty of medicine Ain shams university | ||
| 2Department of Obstetrics and Gynecology Faculty of Medicine – Ain Shams University | ||
| Abstract | ||
| Background: Pre-eclampsia is a pregnancy-specific disorder that has a worldwide prevalence of 5-15%. It is one of the main causes of maternal and perinatal morbidity and mortality globally and accounts for 50000–60000 deaths annually, with a predominance in the low- and middle-income countries. There is a great need to have a test for predication of women at high risk of developing preeclampsia. Aim:This work aimed to assess the accuracy of maternal serum Cff-DNA concentration levels in primigravidas 10-20 weeks gestation as a predictive test for the development of preeclampsia. Materials and Methods: A nested case-control study was conducted on 26 patients with PE and 26 matched controls rimigravidas in 10-20 weeks gestation recruited from Ain-Shams University Maternity Hospital. Laboratory work was done in Ali Khalifa laboratory of the biochemistry department, Faculty of Medicine, Ain-Shams University. Results: The study showed a statistically significant increase median of severe preeclampsia compared to non-severe preeclampsia and control group according to cff-DNA (GE/ml). Also the study results revealed a statistically significant increase median of preeclampsia group compared to control group according to BMI, GA (wks), SBP and DBP, Conclusion: Cff-DNA quantification can be considered as a promising marker for preeclampsia prediction, especially for the development of early-onset or severe preeclampsia. | ||
| Keywords | ||
| Cff-DNA; Preeclampsia; primigravida | ||
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