Correlation Between Umblical Artery Doppler Indices With Neonatal Cord Blood Ischemic Modified Albumin in Diagnosis of Neonatal Asphyxia in High Risk Pregnancy | ||
| Evidence Based Women's Health Journal | ||
| Article 9, Volume 12, Issue 1, February 2022, Pages 69-76 PDF (577.42 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ebwhj.2020.28154.1092 | ||
| Authors | ||
| Alshaimaa Elsayed* 1; ASMAA IBRAHIM2; Mona Elkafrawy3; IMAN AbdRabou4 | ||
| 1Obstetrics and gynecology faculty of medicine for girls , Al-Azhar university | ||
| 2Department of pediatric and neonate Faculty of Medicine For Girls Al-Azhar University.. | ||
| 3obeststric and gynecology Faculty of Medicine for Girls Al-AzharUniversity | ||
| 4Obstetrics and Gynecology Faculty of Medicine for Girls Al-Azhar University | ||
| Abstract | ||
| Background: Neonatal asphyxia is a significant cause of neonatall morbidity and mortality worldwide. Aim: This study aims to is to evaluate the significance of the cord blood ischemia-modified albumin (IMA) level as a diagnostic marker for neonatal asphyxia and to determine the associations of IMA levels with doppler findings in diagnosis of neonatal asphyxia in high risk pregnancy. Materials and Methods: This is a prospective case control study that will be performed at obstetrics and gynecology department at Al-zahraa University Hospital. The study was carried out on 90 pregnant women who are attend the obstetrics department for labour and divided into two groups: Group A:(control group)it was include 30 healthy pregnant women. Group B:(study group) it was include 60 pregnant women with high risk pregnancy. Doppler measurements were obtained from umbilical and middle cerebral arteries,C/P ratio.IMA was measured by ELISA kits and expressed as picomole per milliliter. Results: Ischemia-modified albumin levels were significantly higher in neonates of complicated pregnancies as compared to uncomplicated pregnancies (P<0.001). They were higher in newborns with neonatal asphyxia as compared to healthy controls (P=0.004).The C/P ratio-pulsatility index (PI) showed a significant difference between normal and complicated pregnancies with neonatal asphyxia (P<0.0001). IMA levels were significantly increased in cases with abnormal C/P ratio-PI. Conclusion: Cord blood IMA levels may be accepted as a useful marker in diagnosis of neonatal asphyxia in high risk pregnancy. Abnormal umblical artery Doppler examinations are associated with elevated IMA levels in high risk pregnancy. | ||
| Keywords | ||
| UMBILICAL CORD DOPPLER AND ASPHEXIA | ||
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