Visfatin in Association with Severity and Activity of Primary Osteoarthritis and Rheumatoid Arthritis | ||
| Benha Medical Journal | ||
| Article 10, Volume 38, Issue 1, April 2021, Pages 113-124 PDF (733.06 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2020.130408 | ||
| Authors | ||
| Dalia Allam; Abd El Wahab Shams El Din; Ahmed El Shambaky; Marwa Yehia | ||
| Department of Rheumatology, Rehabilitation and physical medicine, Benha faculty of medicine , Benha University, Egypt | ||
| Abstract | ||
| Background: Visfatin is a one of the recently discovered adipokine that has important pro-inflammatory and catabolic roles in rheumatoid arthritis (RA). Pro-inflammatory cytokines initiate a number of physiological changes that result in the characteristic signs of inflammation. Visfatin may play a role in OA by activating chondrocytes. Along with its cytokine effect, visfatin has an enzymatic activity called nicotinamide-phosphoribosyl-transferase (NAMPT). Objectives: To study the level of Visfatin in RA and OA sera and correlate its levels with activity and severity scores of both diseases. Subjects and methods: A case control study was conducted to assess Visfatin serum level in 20 patients of osteoarthritis and 25 patients rheumatoid arthritis and 20 apparently healthy individuals. Lequesne’s algo-functional Index used for assessment of OA functional impairment , Kellgren and Lawrence for radiological severity and KOFUS for activity , while Larsen's scoring system used for assessment of RA severity and DAS 28 score for activity. Visfatin concentrations in serum measured using a commercially available ELISA kit. Results: Mean Lequesne’s index was 11.2 ± 3.6. According to Kellgren and Lawrence we had one patient G1 , 9 patients GII , 7 patients GIII and 3 patients GIV .Median KOFUS was 5 and it ranged from 3 to 13,. Mean DAS 28 was 4.96± 1.27. As regards Larsen score, mean was 24± 22. There was an overall significance in visfatin between three groups. P value was Conclusion: Visfatin may have a role in the pathogenesis of OA and RA. Furthermore it acts as a potential marker for disease activity and severity of RA as well as severity of OA. | ||
| Keywords | ||
| Visfatin; Rheumatoid arthritis(RA); Osteoarthritis (OA); ELISA kit | ||
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