THE EFFECT OF GENISTEIN AGAINST SCHISTOSOMA MANSONI IN EXPERIMENTALLY INFECTED MICE | ||
| Journal of the Egyptian Society of Parasitology | ||
| Article 15, Volume 50, Issue 3, December 2020, Pages 590-598 PDF (1.05 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jesp.2020.131091 | ||
| Authors | ||
| ISMAIL M. MOHARM1; SALWA F. OSHIBA2; AMANY I. AMMAR1 | ||
| 1Department of Medical Parasitology | ||
| 2Faculty of Medicine | ||
| Abstract | ||
| Schistosomiasis is one of the most significant parasites especially in tropics and subtropics. The only recognized drug used for treatment of all species of Schistosoma is praziquantel (PZQ). Worries about drug resistance motivated the quest for novel drug sources. Genistein, which is a natural product present in soybeans, was assessed for its antischistosomal effects in experimentally Schistosoma mansoni (S. mansoni) infected mice either solely or in association with PZQ. All groups that were infected subjected to portal and mesenteric veins perfusion, evaluation of worm burden, liver and intestinal ova count, and the oogram. Moreover, ultrastructural changes in the worm’s tegument and interleukin IL-1β (IL-1β) levels in infected mice were also assessed. There were significant reductions in the total worm number and egg load of liver and intestine with significant decrease in immature and mature eggs in all groups received treatment in comparison with the infected non treated control one. Tegument of adult worms exposed to genistein exhibited distortion of suckers and erosions with loss of tubercles and spines. There was decrease in the IL-1β level in all treated groups. The best results, in all parameters, were given by combined (genistein & PZQ) treatment. Genistein possessed moderate activity against S. mansoni adults and considered as a good adjuvant to PZQ. | ||
| Keywords | ||
| Schistosoma mansoni; Genistein; praziquantel; in vivo; tegumental alteration; IL-1β | ||
|
Statistics Article View: 200 PDF Download: 237 |
||
