Chronic Graft-versus-Host Disease: An Immunologic Perspective | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 28, Volume 81, Issue 6, October 2020, Pages 2285-2290 PDF (325.36 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2020.131138 | ||
| Authors | ||
| Alaa E. Abd El-Hamid; Enas S. Zahran; Mohamed E. Salim* | ||
| Department of Internal Medicine, Faculty of Medicine, Menoufia University | ||
| Abstract | ||
| Background: Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. Objectives: The aim of this work is to summarize the most recent available data concerning chronic graft versus host disease from biologic, cytogenic and immunopathogenesis and its role in diagnostics therapeutic. | ||
| Keywords | ||
| Allogeneic hemopoietic stem cell transplantation; Chronic Graft Versus Host Disease | ||
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