Association of CCND1 rs603965 Polymorphism with Breast Cancer Risk in North Indian Population | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Article 12, Volume 12, Issue 2, December 2020, Pages 157-167 PDF (699.77 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2020.131306 | ||
| Author | ||
| Naseem Akhter | ||
| Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University, Albaha- KSA | ||
| Abstract | ||
| The potential association of G870A SNP (rs603965) of cyclin D1 gene (CCND1) with susceptibility to breast cancer in the north Indian population was investigated. The study included 230 subjects comprising 115 breast cancer cases and an even number of controls. PCR-RFLP employed for genotyping revealed that the females carrying AA genotype have 2.66- fold increased risk for development of breast cancer in the total cohort (OR 2.66, 95% CI 1.25– 5.67; P= 0.017) compared to GG genotype. Further, a significantly higher risk was also observed in premenopausal women (OR 3.35, 95% CI 1.22– 9.18; P= 0.0310). However, GG and GA genotype are not found associated significantly with breast cancer risk. The results suggest that CCND1 G870A polymorphism influences the genetic susceptibility to breast cancer. Larger studies conducted in diverse populations are needed to ascertain the contribution of these risk alleles to breast cancer risk. | ||
| Keywords | ||
| CCND1; G/A 870 (rs603965); breast cancer; gene polymorphism | ||
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