Utility of Activated Nitriles in the Synthesis of some New Pyridine and Fused Pyridine Derivatives with Anticancer Activity | ||
| Journal of Advanced Pharmacy Research | ||
| Article 2, Volume 5, Issue 1, January 2021, Pages 180-201 PDF (786.74 K) | ||
| Document Type: Research Article | ||
| DOI: 10.21608/aprh.2020.37889.1114 | ||
| Authors | ||
| Aisha Helali1; Marwa Sarg2; Mona Elzoghbi* 3 | ||
| 1Organic Chemistry Department, Faculty of Science (Girls) Al-Azhar University, Cairo, Egypt | ||
| 2Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy (Girls) Al-Azhar University, Cairo, Egypt. | ||
| 3Pharmaceutical Chemistry Department, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt. | ||
| Abstract | ||
| Objective: This study aimed synthesis of pyridine and fused pyridine derivatives based on the importance of these heterocycles as anticancer. Method: Novel pyridine and fused pyridine derivatives 3-35 were synthesized through different chemical reactions. Results: Structures of these compounds were confirmed by spectral and elemental analyses. The obtained compounds were evaluated for their in vitro antitumor activity against liver HepG2 and breast MCF-7 cancer cell lines compared to the reference drug (5-fluorouracil). Conclusion: Compounds 4, 12, 13, 19, 21, 28 and 29 were found to be the most active against both cell lines exhibiting IC50 values ranging from 3.05-11.50 μg/mL and 2.87-6.23 μg/mL against HepG-2 and MCF-7 cell lines; respectively | ||
| Keywords | ||
| Pyridine; Anticancer; HepG2; MCF-7 | ||
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