Saleh, A., Shehata, W., Elhelbawy, M., Elhelbawy, N. (2020). ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO. test, 38(1), 1-18. doi: 10.21608/ejb.2020.136524
Amany Saleh; Wafaa Shehata; Mohammed Elhelbawy; Nesreen Elhelbawy. "ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO". test, 38, 1, 2020, 1-18. doi: 10.21608/ejb.2020.136524
Saleh, A., Shehata, W., Elhelbawy, M., Elhelbawy, N. (2020). 'ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO', test, 38(1), pp. 1-18. doi: 10.21608/ejb.2020.136524
Saleh, A., Shehata, W., Elhelbawy, M., Elhelbawy, N. ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO. test, 2020; 38(1): 1-18. doi: 10.21608/ejb.2020.136524

ASSOCIATION BETWEEN GENETIC VARIANTS OF SINGLE NUCLEOTIDE POLYMORPHISMS OF THE DISCOIDIN DOMAIN RECEPTOR TYROSINE KINASE 1 (DDR1) A/C (RS 2267641) AND GRANZYME B (GZMB) C/T (RS8192917) GENES IN VITILIGO

The Egyptian Journal of Biochemistry and Molecular Biology
Article 1, Volume 38, Issue 1, 2020, Pages 1-18    PDF (900.86 K)
Document Type: Original Article
DOI: 10.21608/ejb.2020.136524
Authors
Amany Saleh1; Wafaa Shehata2; Mohammed Elhelbawy3; Nesreen Elhelbawy* 4
1medical biochemistry and molecular biology,faculty of medicine,menoufia university,shebin elkom,egypt.
2,2Dermatology, Andrology & Sexually Transmitted Diseases (STDs), Faculty of Medicine, Menoufia University
3Clinical Pathology Departments, Faculty of Medicine, Menoufia University
4Medical Biochemistry & Molecular Biology, Faculty of Medicine, Menoufia University
Abstract
Vitiligo manifests as advanced loss of melanocytes with reduced cellular adhesion. Discoidin Domain Receptor Tyrosine kinase1 (DDR1) is a main element affecting cellular adhesiveness associated with vitiligo. Granzyme B (GZMB) has significant role in cytotoxic T-cell induced apoptosis. This study aimed to evaluate the association between genetic variants of single nucleotide polymorphisms of DDR1 A/C (rs 2267641) and GZMB C/T (rs8192917) and the risk of developing vitiligo. The genotypes were investigated using allele discrimination assay comparing 120 patients having non-segmental vitiligo and 100 age and gender matched healthy individuals. We detected a significant prevalence of the CC genotype and C allele of both DDR1 and GZMB polymorphisms in vitiligo patients with early onset and progressive course compared to controls. Our results concluded that DDR1 A/C (rs 2267641) and GZMB C/T (rs8192917) polymorphisms may be risk factors for vitiligo.
 
Keywords
Vitiligo; polymorphism; DDR1; GZMB
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