Intralesional Injection of Bleomycin in Verruca Vulgaris Immunohistochemical and Clinical Study | ||
| Benha Journal of Applied Sciences | ||
| Article 16, Volume 5, Issue 6 part (2), September 2020, Pages 257-261 PDF (704.72 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2020.137173 | ||
| Authors | ||
| E.M. Akl1; A.A. Saleh1; H. Rashad2; M.S. Hakem1 | ||
| 1Dermatology and Venerology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| 2Pathology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| The current examination was an endeavor to evaluate the viability of IL bleomycin infusion for the treatment of verruca vulgaris. Just as to evaluate the results that were experienced during the investigation. This investigation was done on 30 patients grumbling of various verrucae vulgaris. Included 10 ordinary people, biopsy was taken from non sun uncovered skin (lower arm) and recolored by caspse3. 15 of them were biopsied before infusion of bleomycin intralesionally and inspected histologically and immuno-histochemiclly by H&E and caspase 3. similar 15 patients with another verrucae were biopsied after infusion of bleomycin intralesionally in third ,fourth and seventh day after infusion and analyzed by H&E and caspase3. the remainder of verrucae from all patients were infused bleomycin intralesionally like clockwork for 6 meetings most extreme and followed for complete leeway and repeat as long as 3 months. there was factually centrality in articulation and force of caspase 3 shows expanding in apoptosis after infusion, the articulation was cytoplasmic in dispersion and sketchy in design in all cases. intralesional bleomycin is a powerful and very much endured first line treatment in the treatment of verrucae vulgaris paying little mind to patient's age, sex, malady span or being treated before by any modalities. | ||
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