Human Chorionic Gonadotropin Assay in Cervicovaginal Secretions as a Predictor of Preterm Delivary | ||
| Benha Journal of Applied Sciences | ||
| Article 11, Volume 5, Issue 8 part (1) - (2), December 2020, Pages 61-65 PDF (424.94 K) | ||
| Document Type: Original Research Papers | ||
| DOI: 10.21608/bjas.2020.137592 | ||
| Authors | ||
| N.I. Ashmawy; A.A. Shdeed; A.S. Abd EL-Azeem; S.A. Ebied | ||
| Obstetrics & Gynecology Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||
| Abstract | ||
| Preterm birth (PTB) is defined as birth before 37 weeks’ gestation, accounts for 6–10% of all births and is a major contributor to neonatal and infant morbidity and mortality The aim of the current study is to assess the diagnostic accuracy of Beta-subunit of human chorionic gonadotropin (β-HCG) in cervico-vaginal secretion, as a biochemical predictor of preterm labor. A cross sectional study was conducted on(100) women between 24th -36th week of singleton pregnancy. The gestational age was determined by the first day of last menstrual period and confirmed by ultrasound, cervi-covaginal secretion samples was obtained through speculum examination from all the patient, the swab disposed of the sample was quantitatively tested for the level of beta-HCG, the level of beta HCG was measured by the radioimmunoassay method using a commercial kit, and the result was reported in milli-international units per milliliter, the results revealed that there was significant difference between both groups regarding S/D ratio of beta HCG (66.97- 21.45) as range S/D for preterm group was higher than full term group the qualitative test was found to have sensitivity, specificity, PPV, NPV and diagnostic accuracy to predict PTB of 68.33%, 96.06%, 75.93%, 94.35% and 91.79%,respectively, It was found to be more sensitive in the high-risk patients, but more specific in the low risk control group. | ||
| Keywords | ||
| Preterm birth; Predictor; HCG; Cervico-vaginal secretion | ||
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