Synthesis and Biological Activity of Some New Substituted Quinazolin-4(3H)-Ones | ||
| Egyptian Journal of Chemistry | ||
| Article 1, Volume 54, Issue 1, February 2012, Pages 1-15 PDF (480.97 K) | ||
| DOI: 10.21608/ejchem.2011.1376 | ||
| Abstract | ||
| 3- (4-AMINOPHENYL)-2-benzyl-4-oxo-3,4-dihydroquinazoline 1a and 3 - (4 - aminophenyl) - 2 - benzyl - 6 - bromo - 4 - oxo -3, 4 dihydroquinazoline 1b were prepared and diazotized by nitrous acid to give ″2a, b″. The diazonium chloride derivatives were converted to the corresponding 3-arylhydrazono derivatives on treatment with active methylene compounds namely acetylacetone, ethyl acetoacetate and/or ethyl cyanoacetate. The hydrazono derivatives were converted to the corresponding pyrimidino derivatives ″6a-f″, pyrazolo derivatives ″7a-d″ and pyrazoline derivatives ″8a-d″ and ″9a-f″ in order to study their antimicrobial activity. A significant level of activity of the new products was observed. | ||
| Keywords | ||
| 2- Benzyl - 4(3H) quinazolinone - 4 - (3H) - one; 6-Bromo derivative; Aryl hydrazones; β-Diketones and Biological activity | ||
|
Statistics Article View: 296 PDF Download: 551 |
||
