Zalat, Z., Kohaf, N., Alm El-Din, M., Elewa, H., Abdel-Latif, M. (2021). Silymarin: A promising cardioprotective agent. test, 1(1), 13-21. doi: 10.21608/aijpms.2021.52962.1014
Zeinab Zalat; Neveen Kohaf; Mohamed Alm El-Din; Hosny Elewa; Mohamed Mahmoud Mohamed Abdel-Latif. "Silymarin: A promising cardioprotective agent". test, 1, 1, 2021, 13-21. doi: 10.21608/aijpms.2021.52962.1014
Zalat, Z., Kohaf, N., Alm El-Din, M., Elewa, H., Abdel-Latif, M. (2021). 'Silymarin: A promising cardioprotective agent', test, 1(1), pp. 13-21. doi: 10.21608/aijpms.2021.52962.1014
Zalat, Z., Kohaf, N., Alm El-Din, M., Elewa, H., Abdel-Latif, M. Silymarin: A promising cardioprotective agent. test, 2021; 1(1): 13-21. doi: 10.21608/aijpms.2021.52962.1014

Silymarin: A promising cardioprotective agent

Azhar International Journal of Pharmaceutical and Medical Sciences
Article 2, Volume 1, Issue 1, January 2021, Pages 13-21    PDF (567.86 K)
Document Type: Review Articles
DOI: 10.21608/aijpms.2021.52962.1014
Authors
Zeinab Zalat1; Neveen Kohaf* 1; Mohamed Alm El-Din2; Hosny Elewa3; Mohamed Mahmoud Mohamed Abdel-Latif4
1Department of Clinical Pharmacy, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo, Egypt.
2Department of Clinical Oncology, Faculty of Medicine, Tanta University, Tanta, Egypt.
3Department of Pharmacy Practice, Faculty of Pharmacy, Horus University, Dominate City, Egypt.
4Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt.
Abstract
Silymarin ‘milk thistle’ (Silybum marianum) plant, has been used for years for treatment of different diseases such as liver and gallbladder disorders, protecting liver against snake bite and insect stings, mushroom poisoning and alcohol abuse. Silymarin has antioxidant, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulatory, and liver regeneration activities. The cardioprotective activities of silymarin were primarily shown in cisplatin-induced cardiotoxicity in rat models. These effects are due to replenishing endogenous antioxidant enzymes, suppressing neutrophil infiltration, and reducing serum malondialdehyde as the end product of myocardial lipid peroxide. Silymarin treatment protects against reperfusion damage and inflammation by confirming anti-inflammatory and antioxidant actions. Silymarin antioxidant properties is considered responsible for its cardio-protective activities. The mechanisms by which silymarin protects the heart remain largely unexplored. In this review, we will discuss in detail the cardioprotective properties of silymarin.
Keywords
Silymarin; Heart; Cardiotoxicity; Antioxidant; Chemotherapy
Statistics
Article View: 1,196
PDF Download: 1,598