Kenawy, E., Elbarbary, A., Hamada, E. (2019). Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity. test, 40(1), 59-70. doi: 10.21608/djs.2019.139198
El-Refaie Kenawy; Ahmed A. Elbarbary; E. G. I. Hamada. "Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity". test, 40, 1, 2019, 59-70. doi: 10.21608/djs.2019.139198
Kenawy, E., Elbarbary, A., Hamada, E. (2019). 'Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity', test, 40(1), pp. 59-70. doi: 10.21608/djs.2019.139198
Kenawy, E., Elbarbary, A., Hamada, E. Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity. test, 2019; 40(1): 59-70. doi: 10.21608/djs.2019.139198

Modification of Chitosan and Polymethyl methacrylate with 5-Phenyl-1,3,4-oxadiazole Derivatives and their Antifungal Activity

Delta Journal of Science
Article 7, Volume 40, Issue 1, June 2019, Pages 59-70    PDF (1.61 M)
Document Type: Research and Reference
DOI: 10.21608/djs.2019.139198
Authors
El-Refaie Kenawy1; Ahmed A. Elbarbary2; E. G. I. Hamada* 3
1Chemistry Department, Faculty of Science, Tanta University, Egypt. 2Plant Protection
2Chemistry Department, Faculty of Science, Tanta University, Egypt
3Plant Protection Institute, Agriculture Research Center (A.R.C), Egypt
Abstract
Functionalization of chitosan (Cs) and modified polymethylmethacrylate (PMMA) with 5-phenyl-
1,3,4-oxadiazole derivatives was achieved for biological applications. Reaction of 5-phenyl-1,3,4-
oxadiazole-2-thiol (1) with both Cs and functionalized PMMA with 1,2-ethylenenediamine afforded
the grafted polymers 2 and 3, respectively. Additionally, reaction of compound 1 with
ethylchloroformate furnished O-ethyl S-(5-phenyl-1,3,4-oxadiazol-2-yl) carbonothioate (4).
Similarly, grafting of compound 4 with both Cs and functionalized PMMA yielded polymers 5 and
6, respectively. Some of the grafted polymers were characterized using Fourier transform infrared
(FT-IR). The thermal properties of these polymers were investigated using thermo gravimetric
analysis (TGA) which displayed the first degradation of water and 5-phenyl-1,3,4-oxadiazole
derivatives followed by the degradation of the main Cs and PMMA chains. X-ray diffraction (XRD)
explained the crystal structure of the functionalized polymers with the appearance of Cs and PMMA
peaks and the new peaks that referred to oxadiazole moieties. The biological activity of these
polymers was investigated as antifungal agents where compound 1 showed the highest antifungal
activity.
Keywords
5-phenyl-1; 3; 4-Oxadiazole; Chitosan; Polymethylmethacrylate; Antifungal Activity
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