Synthesis and Antibacterial Activity of Schiff base Compounds Based on Poloxamine | ||
| Delta Journal of Science | ||
| Article 8, Volume 40, Issue 1, June 2019, Pages 71-77 PDF (1.53 M) | ||
| Document Type: Research and Reference | ||
| DOI: 10.21608/djs.2019.139205 | ||
| Authors | ||
| El-Refaie Kenawy1; Samar A. Khattab2; Mohamed M. Azaam* 3 | ||
| 1Department of Chemistry, Faculty of Science, Tanta University, Tanta | ||
| 2Department of Chemistry, Faculty of Science, Tanta University | ||
| 3Polymer Research Group, Department of Chemistry, Faculty of Science, Tanta University | ||
| Abstract | ||
| The hydroxyl end groups of Tetronic T1107 were modified with chloroacetyl chloride. The chloroacetylated Tetronic T1107 was then modified to introduce amino group in the side chain by reacting it with ethylenediamine. New Schiff bases were synthesized by the reaction of aminated Tetronic 1107 with different aromatic aldehydes such as p-hydroxybenzaldehyde, vanillin, p-chlorobenzaldehyde, and p-dimethylamino benzaldehyde. The chemical structure of the obtained Schiff bases was confirmed by FT-IR and 1H-NMR spectroscopy. The antibacterial activity of Schiff base compounds was investigated by well diffusion method against gram-negative bacteria (Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris) and grampositive bacteria (Staphylococcus aureus). The results showed that the polymeric Schiff base compounds have a significant inhibiting effect on all the tested microorganisms. It was also found that the antibacterial activity of the Schiff base was higher than that of unmodified tetronic 1107. | ||
| Keywords | ||
| Poloxamine; Schiff base; Antimicrobial Polymers | ||
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