Allam, N., Salem, M., Elbataa, H., Nabieh, M. (2016). Bacterial pathogens associated with severity of HCV infection. test, 37(2), 207-214. doi: 10.21608/djs.2016.139954
Nanis Gamal Allam; Mohamed Labib Salem; Hassan Elbataa; Maii Moustafa Nabieh. "Bacterial pathogens associated with severity of HCV infection". test, 37, 2, 2016, 207-214. doi: 10.21608/djs.2016.139954
Allam, N., Salem, M., Elbataa, H., Nabieh, M. (2016). 'Bacterial pathogens associated with severity of HCV infection', test, 37(2), pp. 207-214. doi: 10.21608/djs.2016.139954
Allam, N., Salem, M., Elbataa, H., Nabieh, M. Bacterial pathogens associated with severity of HCV infection. test, 2016; 37(2): 207-214. doi: 10.21608/djs.2016.139954

Bacterial pathogens associated with severity of HCV infection

Delta Journal of Science
Article 9, Volume 37, Issue 2, December 2016, Pages 207-214    PDF (1.24 M)
Document Type: Research and Reference
DOI: 10.21608/djs.2016.139954
Authors
Nanis Gamal Allam1; Mohamed Labib Salem2; Hassan Elbataa3; Maii Moustafa Nabieh1
1Microbiology section, Botany Department, Faculty of Science, Tanta University, Tanta, Egypt.
2Immunology section, Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt.
3Hepatology, Tropical diseases medicine, Dean of Medicine faculty, Kafr elsheikh University, Egypt.
Abstract
Hepatitis C virus (HCV) is a serious pathogen with epidemic ≥ 170 millions and Egypt considered the highest,
while immunocompromised chronic HCV patients suffer from serious microbial infections especially bacteria. Aim: investigation
of common bacterial infections in patients with chronic HCV in Egypt and its association with HCV severity. Methods: This
clinical study was conducted on chronic HCV patients and healthy individuals, while urine and blood samples were collected
under optimized conditions. Bacteria were isolated from urine samples and identified using VETIK2 system. Flow cytometry was
used for CD56+ and CD3+ levels detection. Alanine/Aspartate aminotransferase (ALT, AST) levels were detected biochemically,
enzyme-linked immunosorbent assay (ELISA) was used for diacylglycerol acyltransferase-1 (DGAT1) level detection and HCV
PCR was performed for viral load detection. The results: showed that Staphylococcus lentus, Staphylococcus aureus, Klebsiella
pneumoniae, Pseudomonas aeruginosa and Eschirechia coli were the common bacterial infections. The slight reduction in
CD3+and CD56+ levels were coincident with the increase of Alt, AST and DGAT1 levels as patients suffered from high HCV
load. Conclusion: HCV patients are immunocompromised and suffer from serious secondary bacterial infections which increased
the severity of HCV infection.
Keywords
Hepatitis C HCV; Lactobacillus acidophilus and Bifidobacterium bifidum; CD3+; CD56+; IFN-α and ribavirin
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