Salivary level of interleukin-17 in patients having atrophic and erosive oral lichen planus before and after treatment with topical steroids (A Controlled clinical trial) | ||
| Egyptian Dental Journal | ||
| Article 8, Volume 67, Issue 1 - January (Oral Medicine, X-Ray, Oral Biology & Oral Pathology) - Serial Number 3, January 2021, Pages 379-385 PDF (446.42 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/edj.2020.48270.1319 | ||
| Authors | ||
| Ahmed Abdel Aziz Hassan1; Mai Elgendi* 2; Olfat Shaker3; Radwa R Hussein4 | ||
| 1Associate Professor of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Ain shamus University, Egypt. | ||
| 2Assistant Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Future University., MSc Oral Medicine, Ain Shams University Egypt. | ||
| 3Professor of Medical Biochemistry, Faculty of Medicine, Cairo University Egypt. | ||
| 4Lecturer of Oral Medicine, Periodontology and Diagnosis, Faculty of Dentistry, Ain shamus University, Egypt. | ||
| Abstract | ||
| Background: The present study was aimed to measure the salivary level of IL-17 in patients having atrophic and erosive Oral lichen planus lesions (OLP) and to evaluate the effect of topical corticosteroids used for treatment of erosive/atrophic oral lichen planus on the level of IL-17 in the saliva. Subjects and methods: The present study was performed on 40 subjects divided into 3 groups Group (I) Twenty patients diagnosed with erosive/atrophic OLP received topical steroid (triamcinolone acetonide0.1%) four times per day for four weeks. Group (II) Ten patients diagnosed with reticular OLP and Group (III) Ten patients with normal mucosa (healthy control Group). Salivary samples were collected before and after treatment in group (I) and once from subjects in group (II) and (III) for determination of IL-17 levels using enzyme-linked immunosorbent assay (ELISA). Results: The mean IL-17 levels in saliva of erosive/atrophic OLP group were statistically significantly higher before treatment with topical steroid than after treatment and both are statistically significantly higher than the reticular group and healthy control subjects. Also, the clinical score and pain visual analogue score values were statistically significantly higher in the erosive/atrophic group before treatment than after treatment. Conclusions: The salivary levels of IL-17 in erosive/atrophic OLP patients was higher than the reticular OLP patients and both are higher than the healthy control subjects, suggesting that IL-17 has a major role in the pathogenesis of OLP and its salivary level may be diagnostic for the severity of the condition of the erosive/atrophic OLP. | ||
| Keywords | ||
| KEYWORDS: IL-17; Oral lichen planus; saliva | ||
|
Statistics Article View: 329 PDF Download: 317 |
||
