A novel green HPTLC method for simultaneous analysis of four antipsychotics in their pharmaceutical formulations: Assessment by Eco-scale | ||
| Records of Pharmaceutical and Biomedical Sciences | ||
| Article 16, Volume 5, Chemistry - Serial Number 1, January 2021, Pages 112-120 PDF (462.74 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/rpbs.2021.57490.1090 | ||
| Authors | ||
| Eman A Abdel Hameed* 1; zaitona abdel Naby2; Alaa El-Gendy3; Gasser KHAIRY4 | ||
| 1Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Port Said University, Egypt. | ||
| 2Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt. | ||
| 3Faculty of Pharmacy - Suez Canal University | ||
| 4Chemistry Department, Faculty of Science, Suez Canal University, Ismailia, Egypt | ||
| Abstract | ||
| Implementing green analytical techniques has been one of the main objectives of the analytical chemistry community for the past two decades. The aim of transitioning to green analytical chemistry is to establish new methods environmentally benign instead of traditional methods. According to WHO, 20 million people worldwide are affected by schizophrenia, and 45 million people worldwide are affected by bipolar disorders. For that, in this work we develop a green HPTLC method to quantify simultaneously the four antipsychotics chloropromazine HCl, asenapine maleate, quetiapine fumarate and aripiprazole in pure form and tablet formulations. In this chromatographic method, separation was performed using silica gel 60 F254 HPTLC plates, the mobile phase composed of binary mixture of green solvents (ethanol : water (9 : 1 v/v)) which gave compact band with Rf values ranged between 0.14 to 0.70 for the drugs. The method was validated for linearity, accuracy, precision, selectivity and robustness according to ICH guidelines. It was assessed for greenness by analytical Eco-scale and compared with reported HPTLC methods for single analysis of these antipsychotics. | ||
| Keywords | ||
| antipsychotics; Analytical eco-scale; HPTLC | ||
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