(2011). Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines. test, 54(4), 565-578. doi: 10.21608/ejchem.2011.1411
. "Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines". test, 54, 4, 2011, 565-578. doi: 10.21608/ejchem.2011.1411
(2011). 'Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines', test, 54(4), pp. 565-578. doi: 10.21608/ejchem.2011.1411
Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines. test, 2011; 54(4): 565-578. doi: 10.21608/ejchem.2011.1411

Synthesis and Tranquillizing Effect of New 1,4-Benzoxazepines

Egyptian Journal of Chemistry
Article 10, Volume 54, Issue 4, August 2012, Pages 565-578    PDF (315.51 K)
DOI: 10.21608/ejchem.2011.1411
Abstract
 SAERIES of new 1,4-benzoxazepin-5(4H)-ones was prepared by …….alkylation of salicylamides with phenacyl bromides followed by cyclodehydration of the resulting amides. Treatment of the 1,4-benzoxazepine-5(4H)-ones with phosphorus pentasulphide afforded the corresponding 1,4-benzoxazepine-5(4H)-thiones. N-alkylation of the 1,4- benzoxazepin-5(4H)-ones and S-alkylation of the 1,4-benzoxazepine-5(4H)-thiones were described. Some of the new compounds were subjected to preliminary screening for their tranquilizing effect.
Keywords
4-Benzoxazepin-5(4H)-ones; 1; 4-Benzoxazepine-5(4H)-thiones; N-alkylation; S- alkylation; Tranquilizers and Diazepam
Statistics
Article View: 284
PDF Download: 354