Disturbances in Thyroid Hormone Metabolism in Rats Exposed to γ- Radiation and Carbon Tetrachloride: The Role of N- acetyl cysteine and Sodium Selenite | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 6, Volume 33, Issue 2, December 2020, Pages 119-131 PDF (1.46 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2021.50419.1107 | ||
| Author | ||
| Nahed Abdel-Aziz* | ||
| Department of Radiation Biology Research, National Center for Radiation Research and Technology, Atomic Energy Authority (EAEA), PO box 29, Nasr City, Cairo, Egypt | ||
| Abstract | ||
| THIS work aims at detecting the disturbances in thyroid hormone metabolism in male rats exposed to liver injury by γ- radiation and/or carbon tetrachloride (CCl4), in addition to investigating the modulatory role of N-acetyl cysteine (NAC) and sodium selenite (Se) supplementation. Subcutaneous injection of CCl4 twice a week for 8 weeks and/or whole-body irradiation (6 Gy, single dose) one day after the last dose of CCl4 induced hepatotoxicity as manifested by elevation of serum alanine aminotransferase and gamma-glutamyl transferase and oxidative stress in liver tissue. Moreover, significant increases were recorded in pro-inflammatory markers: nuclear factor kappa B and interleukin- 1beta levels. This was also accompanied by a significant decrease in the activity of type 1 iodothyronine deiodinase in the hepatic tissue and triiodothyronine and thyroxin levels in serum, while thyroid-stimulating hormone showed a non-significant increase. Histological examination of liver sections showed marked alterations. However, oral supplementation of NAC and Se for 2 weeks after exposure to CCl4 and/or γ- radiation attenuated the changes induced by these toxins. In conclusion, supplementation of NAC & Se may be useful to attenuate thyroid hormone metabolic disturbances associated with liver injury induced by chemical and physical environmental toxins. | ||
| Keywords | ||
| γ-radiation; CCl4; Liver injury; N-acetyl cysteine; Sodium selenite; Thyroid hormones | ||
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