Vitamin D Deficiency in Subclinical Hypothyroid Dysfunction Patients: A Case Control Study | ||
| Benha Medical Journal | ||
| Article 12, Volume 38, Issue 1, April 2021, Pages 137-145 PDF (502.75 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2021.143528 | ||
| Authors | ||
| Medhat Elamawy1; Seham Gouda Ameen2 | ||
| 1Department of internal medicine, Benha faculty of medicine, Benha University, Egypt. | ||
| 2Department of Clinical and Chemical Pathology, Faculty of Medicine, Benha University, Egypt. | ||
| Abstract | ||
| Background: the prevalence of subclinical hypothyroidism worldwide is commoner than the overt disease. Limited studies discussed the vitamin D levels in subclinical hypothyroid patients. Giving vitamin D supplements may prevent form developing overt hypothyroidism. In this cross-sectional case-control study, we described the differences in the vitamin D of adult Saudis with and without subclinical hypothyroid dysfunction. Methods: This is an observational single-center, retrospective, age, and sex matched, case-control study. A total of 60 subjects [41 healthy controls, 19 subclinical hypothyroid case] were included. 25(OH) vitamin D, TSH, free T4 and free T3 are measured in both groups. Results: Subjects with subclinical hypothyroid dysfunction had a significantly lower serum Vitamin D than controls (p value 0.016) although both groups fall below vitamin D sufficiency levels. Correlation is found between both vitamin D and TSH, p value 0.036. but it was found to be less statistically significant positive relation, r value is 0.279, (R square = .078, beta regression coefficient = -.055 and p value <0.0005) Conclusion: Patients with hypothyroid dysfunction showed much lower serum vitamin D compared to controls but it has not that big role in early hypothyroid disorders as shown in less significant relation. | ||
| Keywords | ||
| Vitamin D; Hypothyroidism; Subclinical hypothyroidism | ||
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