MEASUREMENT OF SERUM BIOCHEMICAL LIVER PARAMETERS AND HCV RNA LEVELS FOR DETECTION THE SEVERITY OF HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA | ||
| Journal of Productivity and Development | ||
| Article 5, Volume 26, Issue 1, January 2021, Pages 97-106 PDF (540.37 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jpd.2021.144108 | ||
| Authors | ||
| Mohamed Ebeid* 1; Ibrahim El Sayed2; Ismail Hegzy3; Maha El Mansy4; Samah Mamdouh5; Fatma Khorshed5; Maysa Abd Rabou6 | ||
| 1Biochemistry and Molecular biology Department, Genetic Engineering and Biotechnology Research Institute, Sadat City University, Egypt. | ||
| 2Biochemistry, Faculty of Science , Kafr El-Sheikh University, Egypt | ||
| 3Biochemistry Department, Faculty of Medicine, Al-Azhar University, Egypt. | ||
| 4Clinical and Chemical Pathology, Haematology Department, Theodor Bilharz Research Institute, Egypt | ||
| 5Biochemistry and molecular biology, Theodor Bilharz Research Institute, Egypt. | ||
| 6Medical Laboratories, Faculty of Applied Medical Sciences, October 6 University, Egypt. | ||
| Abstract | ||
| Hepatitis C virus (HCV) is one of the leading causes of chronic liver disease. Hepatocellular carcinoma (HCC) is a major complication associated with HCV virus infection, with significant mortality and morbidity rates. This study aimed to measure biochemical liver parameters and HCV RNA levels for detection the severity of hepatitis C virus- associated hepatocellular carcinoma. The study was conducted on 100 patients, with ages ranging from 36 to 68 years and patients grouped into four groups. The 1 st group served as control group (n= 25),the second group (n=25): Hepatitis C Virus, the third group (n=25): HCV-associated HCC and the fourth group (n=25): After HCC removal and tumor resection. Serum samples were collected from the studied patients. Liver function enzymes (ALT, AST, Alkaline phosphatase) and another function parameters (Albumin and Total bilirubin) were tested to all patients of the studied groups. The results showed that hepatitis C Virus, HCV-associated HCC, and after HCC removal groups had an increase in liver function enzymes, decrease in albumin levels, and an increase in total bilirubin levels which indicate damage in the liver. Viral loads indicated in males infected higher than in females and significantly increased in HCV patients, and a highly significant increase in HCV associated HCC patients. Conclusively, Hepatitis C Virus, HCV-associated HCC, and After HCC removal groups had an increase in liver function enzymes, decrease in albumin levels, and an increase in total bilirubin levels which indicate damage in the liver. Viral loads indicated in males infected higher than females are significantly increased in HCV patients, and a highly significant increase in HCV associated HCC patients. | ||
| Keywords | ||
| Liver parameters; HCV; hepatocellular carcinoma; HCC | ||
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