Nutritional And Biochemical Effects OfGum Arabic On The Pathological Changes Reduction OfAlloxan Induced Diabetic Rats

Egyptian J. of Nutrition Vol. XXXIII No.3 (2018) Nutritional And Biochemical Effects OfGum Arabic On The Pathological Changes Reduction OfAlloxan Induced Diabetic Rats EnsafM. Yassin Nutrition and Food Science Dept, Faculty ofHome Economics, AI­Azhar University, Egypt Abstract Natural substances have been used as a source of medicinal treatments for several decades and plants-based products playa critical role in the treatment of diabetes mellitus (DM) globally. This study was conducted to acquaintancethe effectiveness of gum Arabic (GA)on experimental rats suffered from diabetes mellitus.Thirty six mature male albino rats "Sprague Dawley" strain weighing (160±10 g), were used and divided into two main groups, one was kept as a negative control group (n =6) (G1), while the other was injected infra peritoneally with alloxan monohydrate by a single"'alose of alloxan (1S0mg/kg/B.W.) in 24 hrs fasting animal. This second main group divided into equal five groups (n =6);. The five diabetic groups were as the following; Group (2): was left as positive control and fed on basal diet only. Group (3): was fed on basal diet supplemented with diamacron drl1g1Smg Ikg diet.Group (4): was fed on basal diet supplemented with SO g GA (S%) Ikg diet. Group (5): was fed on basal diet supplemented with 100 g GA (10%)1 kg diet. Group (6): was fed 1

Ensaf M. Yassin on basal diet supplemented with GA (10%) +diamacron drug15mg /kg diet. Biological evaluation; liver enzymes andlipid profile andlipoprotein fractions were evaluatedin addition to blood glucose and antioxidant enzyme (SOD) estimated. Moreover, histopathological investigation of liver carriedout.The obtained results concluded that supplemented diets withGA, especially at 10% of diet, improved the level of blood sugar,liver enzymes and lipid profile levels. Introduction Diabetes Mellitus (OM) is a heterogeneous metabolic disorder characterized byaltered carbohydrate, lipid and protein metabolism which causes hyperglycemiresulting from insufficient insulin secretion, insulin action or both (Mutalik et a/., 2003 and Joseph and Jini, 2011).OM. affects atleast 10% of the population,worldwide. Complications of OM include hypertension, atherosclerosis, microcirculatory disorders, retinopathy, nephropathy, neuropathy andangiopathy (Edem, 2009). Hyperglycemia can cause oxidative stress, which, in turn, may resultin cellular tissue damage. The harmful influence of diabetes on metabolism of tissuesand organs is well known likewise; uncontrolled hyperglycemia can lead todisturbances in the structure and function of organs (Gupta et a/., 2004). ".," : Many hypoglycemic agents, such as the iguanids and sulfonylureas, are usedalone or together with insulin to treat this disease, however these· medications cancause serious side 2