Biological study of the effect of antioxidants both and mix them to chronic renal failure

Egyptian J. of Nutrition Vol. XXXIII No.3 (2018) Biological study of the effect of antioxidants both and mix them to chronic renal failure ...."'...:Tl1a Haji Hassan Ashkanani Home Department, Basic Education The Public Authority for Applied Education and Training, Kuwait Abstract The main present study is the ability of the Vit. E & Selenium) supplement with to prevent on chronic failure in the experimental rats. were randomly divided equal groups and treated four consecutive weeks. group continued to same diet without until the end of the study (control group). second group fed on containing adenine (0.75%, w/w, in diet) as a rnniTrn, group. The third group on adenine diet supplemented with 3g vitamin CI fourth group fed on diet nl""m""nT""" with 900mg vitamin kg diet, and fifth group fed on adenine diet supplemented with 0.1 ppm of selenium as The sixth group on adenine diet supplemented with antioxidants mixture. Results showed that uric acid, urea nitrogen creatinine (mg/dl) of the control group showed increase (PSO,05) the mean of kidneys decrease positive control group fed on adenine containing (selenium antioxidants) as (control -) group. AST and in all treated groups 101

Rasha Haji Hassan Ashkanani recorded significant decrease (P<O.05) when compared with (control +).Histopathological examination of kidneys of rat from group the groups which treated with Vit. C, Vit. E and the mixture of (vitamin C, Vitamin E and selenium) revealed no histopathological changes.Vit. C, Vit.E and selenium improved kidney function and its complications resulting from chronic renal failure. According, it could be recommended that consuming adequate amount of antioxidants from foods and added selenium in the preparation of bread or bakery. Introduction Renal failure is accompanied by oxidative stress, which is caused by enhanced production of reactive oxygen species and impaired antioxidant defense. (Wesen,2011) The suggested therapeutically interventions aimed at reducing oxidative stress in chronic renal failure patients are as follows: 1) Administration of antioxidants [alpha-tecopherol, ascorbic acid, N-acetyl cysteine, reducing glutathione].2) Substances possibly affecting oxidative stress indirectly [erythropoietin, sodium selenate]. (Ben.,et al., 2006).Oxidative stress, increased lipid peroxidation and decreased activity of antioxidant system may contribute to the accelerated development of atherosclerosis in chronic renal failure patient during renal replacement therapy, (Mydlik, et al., 2002). Dietary intake of antioxidants can inhibit or delay oxidation of susceptible cellular substrates and prevent oxidative stress. The phenolic compounds such as flavonoids, phenolic acids, diterpenes, saponins and · tannins have received much attention for their high antioxidative activity (Rice-Even et al., 1996 and Abd EI-Ghany et al., 2011). Therefore, it is important to enrich our diet with 102