Non-Linearity Effect of Low-Doses γ-Radiation on Essential Metals, Lipid Peroxidation and Metallothionein Levels in Rats | ||
| Egyptian Journal of Radiation Sciences and Applications | ||
| Article 4, Volume 24, Issue 1, June 2011, Pages 45-58 PDF (408.52 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejrsa.2011.1453 | ||
| Abstract | ||
| LOW DOSES increase the resistance of the cells or organism to the moderate or severe levels of stress. The present work aimed to investigate the effect of low γ-radiation doses on the essential metals; iron, copper, zinc and calcium (Fe, Cu, Zn & Ca), lipid peroxidation as malondialdehyde (MDA) and metallothionein (MT) in the liver, kidney and testis of rats. Rats were exposed to 0.06, 0.126 and 0.227 Gy at a low dose rate 2.5 mGy/h by two models of exposure, continuous and fractionated (along one and two weeks). The results indicated significant effect between groups and time of exposure models. Trace metals exhibited difference responses in the different tissues particularly before and after 0.126 Gy dose, but certain metals tended to restore the normal levels in continuous and fractionated for one week exposure models at 0.227 Gy. After two weeks increasing in Ca and decreasing in Fe levels and MT levels were observed at the all doses. Zinc levels had not been affected in kidney and testis, controversy effects occurred in liver which increased at 0.227 Gy in all exposure models. Continuous exposure led to elevation in MDA and lowering in MT at 0.126 Gy then reverse effect occurred at 0.227 Gy. In conclusion, low doses γ-radiation exposure has no-linear effect on the essential metals, lipid peroxidation and MT. | ||
| Keywords | ||
| Low doses; γ-radiation; essential metals; Lipid peroxidation; Metallothionein | ||
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