Histological Study and DNA Changes in the Kidneys of Rat Fetuses Maternally Treated with Clarithromycin | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 35, Volume 61, Issue 1, October 2015, Pages 575-590 PDF (1.18 M) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0018762 | ||
| Authors | ||
| Asmaa M. Kandila1; Gabri M. S2; Abdel Razik H. Farrag3; Basma N. Hassan2; Doaa Ezz-Eldin I. S2 | ||
| 1Pharmacology Department, National Organization for Drug Control and Research, Giza, Egypt | ||
| 2Zoology and Entomology Department, Faculty of Science, Helwan University, Cairo, Egypt | ||
| 3Pathology Department, Medical Research Division National Research Centre, Cairo, Egypt | ||
| Abstract | ||
| Introduction: macrolide antibiotics are a class of potent and well established antimicrobials that also possess anti-inflammatory and/or immunomodulatory properties. Because of their size, lower levels of macrolides are able to reach the developing fetuses. Materials and method: the pregnant rats were orally administered with clarithromycin at early and late gestational periods. The 20 day-old fetuses were dissected for excision of the kidney. Half of the kidney was processed and stained with H & E, PAS, Masson’s trichrome and Feulgen techniques then followed by morphometric measurements and statistical study. The other half of the kidney was preserved for DNA fragmentation assay.Results: This study revealed that clarithromycin administration to pregnant rats showed different histopathological, histochemical and DNA changes in the kidneys of their fetuses. Conclusion: Administration of the antimicrobial agent; clarithromycin at early and late gestational periods exhibits nephrotoxicity in the developing fetuses. | ||
| Keywords | ||
| clarithromycin; Antimicrobial drug; Rat fetuses; kidney | ||
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