Prevalence and Risk Factors of Overt- and Occult Hepatitis C Virus Infection among Chronic Kidney Disease Patients under Regular Hemodialysis in Egypt | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 41, Volume 61, Issue 1, October 2015, Pages 653-669 PDF (568.94 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0018768 | ||
| Authors | ||
| Essam A. El-Moselhy* 1; Ayman Abd El-Aziz2; Salwa A. Atlam3; Raed H. Mnsour4; Hesham H. Amin5; Tarek H. Kabil6; Ayman S. El-Khateeb7 | ||
| 1Departments of Community and Occupational Medicine Faculty of Medicine, Al-Azhar | ||
| 2Internal Medicine Faculty of Medicine, Al-Azhar | ||
| 3Departments of Community and Occupational Medicine Faculty of Medicine Tanta University | ||
| 4Tropical Medicine Faculty of Medicine, Al-Azhar University | ||
| 5Clinical Pathology Faculty of Medicine, Al-Azhar University | ||
| 6Medical Microbiology & Immunology Faculty of Medicine, Al-Azhar University | ||
| 7Departments of Community and Occupational Medicine El-Menia University | ||
| Abstract | ||
| Background: hepatitis C virus (HCV) infection is a major health problem. It is more prevalent among chronic kidney disease (CKD) patients. Occult HCV infection, a new, entity has been described. Aims: to find out prevalence of occult HCV infection among CKD patients under regular hemodialysis (RHD) and to define epidemiology of HCV infection among them. Patients and Methods: a sample of 100 CKD patients under RHD was recruited. A questionnaire form was used to collect data. HCV-RNA was tested in serum to detect overt HCV infection patients. HCV-RNA was tested in peripheral blood mononuclear cells of undetected HCV-RNA patients’ serum to determine those with occult HCV infection. Rest of the patients was considered HCV free. Biochemical tests were done to all patients. Results: prevalence of overt and occult HCV infection among CKD patients under RHD was 34.0% and 27.3%, respectively. Liver and renal function tests were significantly higher among the overt and occult HCV patients compared to negative HCV patients. Liver function tests were significantly lower among the occult compared to overt HCV patients. Overt HCV patients had significant risk factors compared to negative HCV patients; age group 40-59 years (OR=9.34) and rural residence (OR=3.14). Also, significant clinical risk factors were the overweight, history of blood transfusion ≥5 times/year, history of nonmedical bloody manipulations, and history of IV drug abuse (OR=3.23, 5.96, 8.28, 7.08, respectively). Occult HCV patients had significant risk factors compared to negative HCV patients; age group ≥60 years and rural residence (OR=6.25 and 6.73, respectively). Significant clinical risk factor was the history of nonmedical bloody manipulations (OR=11.5). Conclusions and Recommendations: prevalence of overt- and occult HCV infection is high in CKD patients under RHD; this has important clinical and public health implications. There are many significant socio-demographic and clinical risk factors for these infections. A close monitoring of the HD patients and testing them for HCV-RNA in PBMCs yearly to adopted a proper management. Also, more studies on bigger number of patients are required to understand real epidemiology of this health problem. | ||
| Keywords | ||
| CKD; Hemodialysis; overt HCV; Occult HCV; prevalence; HCV-RNA; PBMCs; risk factors | ||
|
Statistics Article View: 290 PDF Download: 416 |
||
