Role of Local injection of 1, 25 Dihydroxycholecalciferol in prevention of Post orthodontic Relapse in uremic Rabbits | ||
| Egyptian Orthodontic Journal | ||
| Article 6, Volume 58, December 2020, December 2020, Pages 61-68 PDF (331.14 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eos.2021.57397.1011 | ||
| Authors | ||
| Mostafa Kamal Abdo* 1; marwa khairallah2; nessren mahmoud Abd el-rady3; mohamed elsayed4; Ahmed shawky hashem5; wael Refai6; Mohamed Gaber Elshal7 | ||
| 1instructor at faculty of Dentistry, Aswan university, department of orthodontics | ||
| 2associate professor in Nephrology department faculty of medicine assiut university | ||
| 3Lecturer of medical physiology , faculty of medicine assiut university | ||
| 4lecturer of orthodontics faculty of dentistry minia university | ||
| 5associate professor of orthodontics faculty of dentistry minia university | ||
| 6Head of orthodonntic department , faculty of dentistry, minia university | ||
| 7Lecturer of orthodontics faculty of dentistry minia university | ||
| Abstract | ||
| Objective: this study aimed to evaluate the effect of local injection of vitamin D 1, 25 Dihydroxycholecalciferol (VD) by means of measuring OTM and bone density by computerized tomography the number of osteoclasts during orthodontic relapse in uremic New Zealand rabbits after induced nephropathy. Materials and Methods: This study is in vivo experimental research. A total of 34 male New Zealand rabbits were used in the study, which were randomly split into three groups, control group (CG), uremic group(CKD G) and uremic with locally injected VD (CKD with VD G) . All rabbits were given an orthodontic force of 60 cN using a NITI 3-spin coil spring that was activated for 15-18 days and then conditioned to be passive. Through this phase, the CKD with VD group was locally injected with VD once every week for 4 weeks. CT measurements and histological analysis were formed at 18 days, after removal of the Orthodontic appliances and after 38 days, Data were analyzed statistically using an independent t-test (p < 0.05). Results: The post OTRM was significantly lower in the CKD with VD injection than in the CKD (P=0.01). The number of osteoclasts in the CKD with VD group was significantly lower than that in the CKD group (p = 0.021). Conclusion: locally injected VD can prevent post orthodontic tooth relapse movement by suppressing osteoclastogenesis and decreasing osteoclasts number in uremic rabbits. | ||
| Keywords | ||
| orthodontic relapse; vitamin D3; chronic kidney disease; 1; 25 Dihydroxycholecalciferol | ||
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