(2003). ALUMINIUM TOXICITY IN RATS : THE ROLE OF TANNIC ACID AS ANTIOXIDANT سمية الألمونيوم على الفئران: دور حامض التانيک کمضاد للأکسدة. test, 6.2(6.2), 1-14. doi: 10.21608/auber.2003.150957
. "ALUMINIUM TOXICITY IN RATS : THE ROLE OF TANNIC ACID AS ANTIOXIDANT سمية الألمونيوم على الفئران: دور حامض التانيک کمضاد للأکسدة". test, 6.2, 6.2, 2003, 1-14. doi: 10.21608/auber.2003.150957
(2003). 'ALUMINIUM TOXICITY IN RATS : THE ROLE OF TANNIC ACID AS ANTIOXIDANT سمية الألمونيوم على الفئران: دور حامض التانيک کمضاد للأکسدة', test, 6.2(6.2), pp. 1-14. doi: 10.21608/auber.2003.150957
ALUMINIUM TOXICITY IN RATS : THE ROLE OF TANNIC ACID AS ANTIOXIDANT سمية الألمونيوم على الفئران: دور حامض التانيک کمضاد للأکسدة. test, 2003; 6.2(6.2): 1-14. doi: 10.21608/auber.2003.150957

ALUMINIUM TOXICITY IN RATS : THE ROLE OF TANNIC ACID AS ANTIOXIDANT سمية الألمونيوم على الفئران: دور حامض التانيک کمضاد للأکسدة

Assiut University Bulletin for Environmental Researches
Article 1, Volume 6.2, Issue 6.2, October 2003, Pages 1-14    PDF (1.22 M)
Document Type: Original Article
DOI: 10.21608/auber.2003.150957
Abstract
ABSTRACT :




Prospective studies suggest that tea may protect against oxidative stress that induced tissue damage. A potential mechanism for such effect by polyphenolic antioxidants tannic acid derived from tea was evaluated in this study. Treatment of rats with aluminium chloride for 80 days caused moderate toxicity on liver, kidney’s and spleen as shown by elevation of free radicals (lipid peroxidation and nitric oxide) and reduction of antioxidants (superoxide dismutase, catalase, gluathione transferase, and glutathione and vitamin E) as well as histopathological changes. However, improvement was noticed in the rats treated with tannic acid in addition to aluminium chloride. This study proved that tannic acid has a role as an antioxidant in protection of rats from the aluminum toxicity.
 
أشارت دراسات عديدة سابقة إلى مقدرة الشاى على حماية الخلايا والأنسجة من الإجهاد التأکسدى، ولهذا تم فى هذه الدراسة استخدام حامض التانيک أحد مکونات الشاى کمضاد للأکسدة. وتم فى هذه الدراسة تعريض الفئران لکلوريد الألمونيوم (30 مجم/کجم من وزن الجسم) لمدة 80 يوماً مما تسبب فى سمية متوسطة على کبد، کلى وطحال هذه الفئران، وذلک من خلال زيادة نسبة الشوارد الحرة (الأکسدة الفوقية للدهون وأکسيد النيتريک)، ونقص فى مضادات الأکسدة (السوبر أکسيد ديسميوتيز، الکتاليز والجلوتثيون تراسنفيريز والجلوتاثيون وفيتامين هـ). علاوة على التغيرات الباثولوجية. قد لوحظ تحسن واضح فى هذه التغيرات فى الفئران التى تم معالجتها بحامض التانيک مع کلوريد الألمونيوم. وقد اتضح من هذه الدراسة دور حامض التانيک کمضاد للأکسدة فى التقليل من سمية کلوريد الألمونيوم فى الفئران.
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