Amelioration of Insulin Resistance in Rats Treated with Rice Bran Oil | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 11, Volume 65, Issue 1, October 2016, Pages 547-552 PDF (288.39 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0033763 | ||
| Authors | ||
| Sohaier, A. Abd Elbast1; Mervat, A. Ahmed1; Elham, A. Ahmed1; Laila, A. Rashed2; Mona, A. Mohamed3 | ||
| 1Zoology Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt | ||
| 2Biochemistry Department, Faculty of Medicine, Cairo University, Cairo, Egypt | ||
| 3Biochemistry Unit, Chemistry Department, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt | ||
| Abstract | ||
| Background: insulin resistance (IR) is a pathological condition characterized by inadequate peripheral tissue metabolic response to circulating insulin. It plays pathophysiological role in type 2 diabetes mellitus (T2DM). High dosage of fructose in the diet (60 g/100 g diet) may induce insulin resistance accompanied by deleterious metabolic consequences including hyperglycemia and hyperinsulinemia. Rice bran oil (RBO), is a rich source of antioxidants especially γ-oryzanol, α-tocopherols and tocotrienols which contribute to high oxidative stability, longer shelf life than other edible oils and high antioxidant property against free radicals. The present work was undertaken to study if the addition of rice bran oil in rat’s diets ameliorate the insulin resistance. Materials and methods: to achieve this target, plasma fasting glucose, serum insulin and calculated HOMA-IR, which assesse the presence of insulin resistance, was evaluated. Serum lipid profile (cholesterol, triglycerides, high-density lipoprotein- cholesterol (HDL) and low-density lipoprotein- cholesterol (LDL) was also evaluated. In addition, the oxidative stress was assessed through hepatic malondialdehyd (MDA) as an oxidative biomarker and the antioxidant enzyme superoxide dismutase (SOD) was also estimated. Results: RBO ameliorated HOMA-IR, oxidative biomarker (MDA) and increased SOD activity. Conclusion: high fructose diet induced oxidative stress which lead to insulin resistance, this was ameliorated by addition of RBO. | ||
| Keywords | ||
| Insulin Resistance; Oxidative Stress; rice bran oil | ||
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