The Potential Protective Effect of Stem Cell Enhancer on Chronic Bisphenol-A Treated Female Albino Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 15, Volume 63, Issue 1, April 2016, Pages 248-257 PDF (519.74 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0023853 | ||
| Authors | ||
| Eman G. E. Helal* 1; Rasha A. A. El sayed* 1; Hoda M. Abu-Taleb2 | ||
| 1Department of Zoology, Faculty of Science, Al-Azhar University (Girls), Cairo, Egypt | ||
| 2Department of Environmental Research, Theodor Bilharz Research Institute, Cairo, Egypt | ||
| Abstract | ||
| Background: The xenoestrogen, bisphenol-A (BPA), is a worldwide food contaminant with endocrine disruptor activity that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of these substances. Aim of the work: The present study was designed to determine if the usage of stem cell enhancer (SE) moderates the physiological changes occasioned by exposure to BPA in the female albino rats. Materials and Methods: This study was performed on thirty female albino rats with an average 100-120 g body weight. The animals were divided into three groups; Group I (Control untreated-group), Group II (bisphenol–A treated group) and Group III (treated group orally supplied with bisphenol –A then treated with stem cell Enhancer (SE)). Serum was separated and used for estimation of hormonal levels [estradiol, progesterone, prolactin (PRL), follicle-stimulating hormone (FSH) and luteinizing hormone (LH)], some biochemical parameters (liver enzymes, kidney function, glucose and lipid profile) and CA-125 and CA 15-3 tumor markers. Results: The biochemical results showed marked significant increase (P<0.01) in the enzyme activities [aspartate aminotransferase (ASAT), alanine aminotransferase (ALAT) and alkaline phosphatase (ALP)],urea and creatinine in bisphenol–A treated group when compared to the control group. These parameters were significantly reduced in the group treated with stem cell enhancer as compared to bisphenol –A treated group . Decline in the concentration of lipid profile with increase in high density lipoprotein cholesterol (HDL- C) levels in the stem cell treated group as compared to bisphenol-A group were observed. There was a significant elevation in prolactin, FSH and tumor marker levels concomitant with a significant reduction in LH levels in bisphenol-A treated group compared to the control group. These results were changed to values very close to control by using the stem cell enhancer. Conclusion: It could be concluded that bisphenol-A has dangerous effects on liver and kidney functions as well as on lipid profile, female hormones and tumor markers level. So, we recommended minimizing the utililizing of this compound and the use of some protective materials as stem cell enhancer to protect people from its hazardous effects. | ||
| Keywords | ||
| BPA ( bisphenol- A); Stem Cell Enhancer; tumor markers; kidney and liver function tests | ||
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