Role of Ginseng as Hepatoprotective, Antioxidant and Anti-Inflammatory against Methotrexate Induced Liver Injury in Rats. | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 12, Volume 62, Issue 1, January 2016, Pages 105-108 PDF (264.53 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0021419 | ||
| Author | ||
| Gehan A. Youssef | ||
| Physiology Department , Faculty of Medicine (Girls), Al-Azhar University. | ||
| Abstract | ||
| Background Ginseng, an ancient and famous medicinal herb in the Orient, has been used as a valuable tonic and for the treatment of various diseases including hepatic disorders. Ginseng extracts and individual ginsenosides have shown a wide array of beneficial role in the regulation of regular liver functions and the treatment of liver disorders. Objective: This study tries to determine the hepatoprotective , antioxidant and anti-inflammatory effects of ginseng on Methotrexate (MTX)-induced hepatotoxicity Materials and Methods: forty rats (weigh 150-180 g) were used. The rats were kept in animal house for one week and had access to water and food . Temperature was kept at 37 °C. After one week, the rats were randomly divided into four equal groups: Group (A) (control) received normal saline ; group (B )received Ginseng(1.8 ml/kg/day) orally ; group( C) received MTX (100 μg/kg) intraperitoneally and group (D) received MTX (100 μg/kg) intraperitoneally with ginseng (1.8 ml/kg/day) orally. After six weeks, the rats were decapitated and evaluation of liver function was done. Results: Ginseng treatment markedly suppressed the serum alanine aminotransferase (ALT) , aspartate aminotransferase (AST) and serum gama glutamil transpeptidase (λGTP) activiteis . Ginseng was attributed to stimulate anti-oxidant protein contents, such as glutathione peroxidase (GPX). The marked increase of proinflammatory cytokines ( TNF α ) in MTX treated rats group was additionally attenuated by ginseng, Conclusion : Ginseng effectively prevent liver injury, mainly through down regulation of oxidative stress and inflammatory response. | ||
| Keywords | ||
| Ginseng; Methotrexate; Liver; anti-inflammatory activity; antioxidant | ||
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