Development of Green Spectrophotometric Method for Determination of Metoclopramide Hydrochloride | ||
| Egyptian Journal of Chemistry | ||
| Article 23, Volume 64, Issue 7, July 2021, Pages 3451-3456 PDF (391.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.43857.2923 | ||
| Authors | ||
| Enas S. Thanoon* 1; Abdussamed M.A. Saeed2 | ||
| 1Department of chemistry , college of science university of Mosul | ||
| 2Section of Basic Sciences, College of Agriculture and Forestry, University of Mosul, Mosul, Iraq | ||
| Abstract | ||
| A simple, sensitive and green spectrophotometric method for the determination of metoclopramide hydrochloride (MTC) has been developed. The method is based on the reaction of MTC with p-dimethylaminobenzaldehyde (DAB) in acidic aqueous medium (pH 2) in the presence of anionic surfactant sodium dodecyl sulfate (SDS) to give a yellow colored Schiff’s base with a maximum absorbance at 452 nm. Obedience to Beer’s law is achieved in the concentration range 0.2–18.0 µg ml-1 (5.6×10-7 - 5.1×10-5 mol l-1), with relative error about 1%, relative standard deviation of less than 0.8% and molar absorptivity 3.02×10-4 l mol-1cm-1. The effect of the presence of some common pharmaceutical additives has been investigated. The developed procedure has been successfully applied to the determination of the drug in pharmaceutical formulations. | ||
| Keywords | ||
| Metoclopramide hydrochloride; p-Dimethylaminobenzaldehyde; Spectrophotmetric determination; Sodium dodecyl sulfate | ||
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