MS, G., MA, I., DH, A., BN, H. (2014). Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits. test, 57(1), 565-579. doi: 10.12816/0018489
Gabri MS; Ibrahim MA; Abd El-kader DH; Hassan BN. "Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits". test, 57, 1, 2014, 565-579. doi: 10.12816/0018489
MS, G., MA, I., DH, A., BN, H. (2014). 'Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits', test, 57(1), pp. 565-579. doi: 10.12816/0018489
MS, G., MA, I., DH, A., BN, H. Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits. test, 2014; 57(1): 565-579. doi: 10.12816/0018489

Histpathological and Immunohistochemical Changes Induced by Contraceptive Pills in the Cervix of Female Rabbits

The Egyptian Journal of Hospital Medicine
Article 18, Volume 57, Issue 1, October 2014, Pages 565-579    PDF (1.1 M)
Document Type: Original Article
DOI: 10.12816/0018489
Authors
Gabri MS1; Ibrahim MA2; Abd El-kader DH3; Hassan BN2
1Department of Zoology and Entomology, Faculty of Science, Helwan University.
2Department of Zoology and Entomology, Faculty of Science, Helwan University
3Department of Histology, Faculty of Medicine, Cairo University
Abstract
Introduction: oral contraceptive pills (OCPs) are the most popular form of hormonal contraception in young women.        
Aim of the work: the present study focused on evaluating the effects of two different contraceptive pills including combined pills (estrogen and progesterone) and mini pills (progesterone only) on the  cervix of female rabbit.                                           
 Material and methods: after three months of daily oral administration of these contraceptive pills the animals were sacrificed. The excised organs were dissected, processed and stained with H & E, PAS reaction and Masson’s trichrome stain and orcein stain. This was followed by morphometric measurements and statistical study. Results: this study revealed that contraceptive pills administration - specially the combined one - caused marked alterations in the form of hyperplastic cervical mucosal cells and hypertrophied muscular layer. Also, there was a significant increase in collagenous and elastic fibres content in the muscular layer of the cervix. There was also a statistically significant increase in PAS positive materials in the lumina of the mucosal glands of the cervix. All these changes were less marked in the case of mini pill treatment                                                                                    
Conclusion: pills of progesterone only showed marked histopathological change, in the cervix as a contraceptive mean, but in less manner than the combined pills (estrogen and progesterone).                                                      
 
Keywords
combined pills – mini pills – cervix – hyperplasia
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