Moustafa, M., Alazzounui, A., Gabri, M. (2014). Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes. test, 57(1), 598-611. doi: 10.12816/0008491
Maiada Moustafa; Ahmed Said Alazzounui; Mohamed Said Gabri. "Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes". test, 57, 1, 2014, 598-611. doi: 10.12816/0008491
Moustafa, M., Alazzounui, A., Gabri, M. (2014). 'Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes', test, 57(1), pp. 598-611. doi: 10.12816/0008491
Moustafa, M., Alazzounui, A., Gabri, M. Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes. test, 2014; 57(1): 598-611. doi: 10.12816/0008491

Histological and Biochemical Evaluation of the Effects of Some Antioxidants on Aged Testes

The Egyptian Journal of Hospital Medicine
Article 20, Volume 57, Issue 1, October 2014, Pages 598-611    PDF (2.24 M)
Document Type: Original Article
DOI: 10.12816/0008491
Authors
Maiada Moustafa1; Ahmed Said Alazzounui2; Mohamed Said Gabri2
1Department of Zoology and Entomology, Faculty of Science, Helwan University
2Department of Zoology and Entomology, Faculty of Science, Helwan University.
Abstract
Background: Different studies have demonstrated that aging clearly affects male fertility which may be attributed to the androgen deficiency. Reactive oxygen species play a central role in the pathophysiology in the aged-related decrease in male fertility. Some antioxidants have ameliorative effects on different aged organs.
Material and Methods: The present study aimed to evaluate the effects of some antioxidants on aged testes. Ten adult and fifty aged male albino rats (Rattus albus) were divided into six groups. Group I (control adult), Group II (control aged), Group III (Vitamin E-treated aged), Group IV (Vitamin C-treated aged), Group V (Zinc sulphate-treated aged), Group VI (Vitamin E-, Vitamin C- and Zinc Sulphate-treated aged). Vitamin E, Vitamin C and Zinc were administrated in doses 2.52 mg, 3.15 mg and 0.693 mg, respectively. Histological and ultrastructural evaluation of the testes were examined as well as Follicle stimulating hormone (FSH), Luteinizing hormone (LH), total and free testosterone levels in the serum were measured. Counting the number of litters per animal and the teratogenic effects was noticed. Results:  Giving zinc alone or combined with other antioxidants gave better ameliorative effects on the testicular structure and hormonal levels in the serum. No teratogenic effects of the aged animals`offspring were noticed.
 
Keywords
aging; testis; zinc; Vitamin E; vitamin c; combined antioxidants
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