High‑Performance Liquid Chromatography‑Fingerprint Analyses, In vitro Cytotoxicity, Antimicrobial and Antioxidant Activities of the Extracts of Ceiba speciosa Growing in Egypt | ||
| Egyptian Journal of Chemistry | ||
| Article 17, Volume 64, Issue 4, April 2021, Pages 1831-1843 PDF (1.43 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.58716.3267 | ||
| Authors | ||
| Abdel-Wanes Anter Abdel-Aziz* 1; Nehal M Elwan2; magda Ahmed Abdallah3; Rasha Shaaban Shaaban4; Nadia Sayed Osman5; Mona AbelMotegally Mohamed1 | ||
| 1Theodor Bilharz Research Institute | ||
| 2chemistry department, faculty of science, cairo university | ||
| 3department of chemistry, faculty of science, cairo university | ||
| 4Biochemistry department, TBRI | ||
| 5medicinal chemistry, TBRI | ||
| Abstract | ||
| ackground: Cancer diseases and microbial resistance are serious health diseases related to oxidative stress and infectious diseases. The risk can be reduced by using plants rich in polyphenols. Methodology: Different solvent extracts from leaves of Ceiba speciosa (C.s) were evaluated for their biological and chemical activities. Also, the chemical profiles were investigated via high‑performance liquid-chromatography (HPLC) fingerprint analyses. Results: the leaves from Ceiba speciosa collected from the Zoo garden in Egypt, showed a moderate cytotoxicity against HepG2 in extracts; petroleum ether, ethyl acetate, dichloromethane, while weak-cytotoxicity in butanol, methanol extracts and non-cytotoxicity in water extract. Moreover, high antimicrobial activities were showed within dichloromethane, petroleum ether extracts, while a moderate antimicrobial activities were showed in methanol, ethyl acetate extracts, and low antimicrobial activities were showed in both of butanol and water extracts. On the other side, a strong antioxidant activities were recorded within extracts; dichloromethane and methanol while the least antioxidant activity was recorded within water extract. High performance liquid-chromatography (HPLC) fingerprint analyses is done for all fractions, this finding provides an insight into the usage of the tested species as a source of naturally occurring cytotoxic, antimicrobial and antioxidant agents | ||
| Keywords | ||
| Key words: Antimicrobial; antioxidant (DPPH); Bombacae; Ceiba speciosa; Cytotoxicity; High‑performance liquid chromatography‑fingerprint analyses | ||
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