Effect of Glutamic Acid as Additional Monomer in Biodegradable Poly(xylitol Sebacate Glutamate) Polymer | ||
| Egyptian Journal of Chemistry | ||
| Article 5, Volume 64, Issue 6, June 2021, Pages 2783-2787 PDF (544.49 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejchem.2021.54273.3128 | ||
| Authors | ||
| Noor Faezah Mohd Sani* 1; Nur Afiqah Jafri2; Noor Aishatun Majid2; Nor Alifah Rosaidi2; Munirah Onn3 | ||
| 1Department of Chemistry, Faculty of Applied Sciences, Universiti Teknologi MARA, Perak Branch, Tapah Campus, Tapah Road, 35400 Perak, Malaysia | ||
| 2University Teknologi Mara Perlis Branch, Arau Campus, 02600 Perlis Malaysia | ||
| 3University Teknologi Mara Johor Branch, Pasir Gudang Campus, 81750 Masai, Johor Malaysia | ||
| Abstract | ||
| Xylitol-based polyesters such as poly(xylitol sebacate) PXS are said to be the potential materials for tissue engineering due to their adjustable mechanical and degradation properties. However, the result indicated that the elastomers are very soft and have a low elongation at break. Therefore, to increase the mechanical strength and minimize the degradation rate, glutamic acid was added as the third monomer into the PXS. Novel Poly (xylitol Sebacate Glutamate) (PXSG) was successfully synthesized through melt polycondensation without using any harsh solvents and catalysts. The mixture was synthesized at 120°C for about 8 hours. Post polymerization process was carried out in the oven at 100 °C for three days to develop the crosslink network formation. Several testing and characterization were conducted to evaluate the effect of glutamic acid concentration in the polymer. From the result, FTIR spectroscopy confirmed the ester bond formation, tensile strength, and Young's modulus increased significantly while the percent of elongation at break and degradation rate decreased as the glutamic acid ratio increased. | ||
| Keywords | ||
| Biodegradable polymer; Tissue engineering; Polyxylitol; Glutamic Acid; Polymer Scaffolding | ||
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