The Potency of Some Natural Products on Dimethyl Benz(A)antheracene(DMBA) Induced Hepatotoxicity in Rats | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 31, Volume 53, Issue 1, October 2013, Pages 1036-1048 PDF (281.47 K) | ||
| Document Type: Original Article | ||
| DOI: 10.12816/0001666 | ||
| Authors | ||
| Wafaa El Kholy; Hanaa Serag; Asharf zakaria; Aziza El Metwaly | ||
| Zoology department ,Faculty of Science,Mansoura University, Egypt | ||
| Abstract | ||
| Aim of the work:the present study was carried out to investigate the possible ameliorating effects of three herbs: hops(H) 1.5g/kg diet , rosemary(R) 5g/kg diet and cat's claw (C C) 1.7g/kg diet on hepatic toxicity induced by 7,12-Dimethyl benz(A)antheracene , a hydrocarbon involves various negative consequence for human health and ecosystems conversation .Results:in this work,48 female rats at 50 day of age were divided into 8 groups; control ,hops(H), rosemary(R), cat's claw(CC),DMBA, DMBA+H,DMBA+R and DMBA+CC groups.Results:the results indicated that a single intraperitonial (i.p) dose of DMBA (30mg/Kg b.W) caused significant decrease in the percentage of body weight gain, but an increase in the hepatosomatic index. In addition , the results illustrated an increase in the liver malondialdehyde (MDA) contents and hydrogen peroxide levels (H2O2) accompanied by significant decrease in reduced glutathione (GSH) content and superoxide dismutase (SOD) and glutathione-S-transferase (GST) activities.The results, also reported significant decrease in serum total proteins, total albumin , globulin and liver total protein but serum total bilirubin was significantly elevated in the DMBA intoxicated group. Furthermore, aspartate aminotransaminase (ASAT), alanine aminotransaminase (ALAT) , γ-glutamyltransferase (GGT) and alkaline phosphatase (ALP) activities were significantly increased in serum but significantly decreased in the liver. On the other hand, intake of hops, rosemary and cat's claw minimize the disturbances observed in most of the tested parameter's resulted from DMBA administration and improve the liver functions mostly in the following order, rosemary ˃ hops ˃ cat's claw. Conclusion: it can be concluded that intake of such herbs (hops , rosemary, cat's claw)may be effective in reducing DMBA toxicity. | ||
| Keywords | ||
| natural products; Hepatotoxicity; Rats | ||
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