Abdallah, N., Mohamed, M., Amien, N., Nada, A., Mohamed, M. (2013). The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.. test, 52(1), 599-607. doi: 10.12816/0000596
N. M. Abdallah; M. R. Mohamed; N. E. Amien; A. S. Nada; M. A. Mohamed. "The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.". test, 52, 1, 2013, 599-607. doi: 10.12816/0000596
Abdallah, N., Mohamed, M., Amien, N., Nada, A., Mohamed, M. (2013). 'The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.', test, 52(1), pp. 599-607. doi: 10.12816/0000596
Abdallah, N., Mohamed, M., Amien, N., Nada, A., Mohamed, M. The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.. test, 2013; 52(1): 599-607. doi: 10.12816/0000596

The Protective Value of Hesperidin in Mitigating the Biochemical Perturbations and Trace Element alterations induced by Acrylonitrile in Rats.

The Egyptian Journal of Hospital Medicine
Article 12, Volume 52, Issue 1, July 2013, Pages 599-607    PDF (351.33 K)
Document Type: Original Article
DOI: 10.12816/0000596
Authors
N. M. Abdallah1; M. R. Mohamed1; N. E. Amien2; A. S. Nada2; M. A. Mohamed2
1Department of Biochemistry, Faculty of Science, Ain Shams University
2Department of Drug Radiation Research, National Center for Radiation Research and Technology, Atomic Energy Authority.
Abstract
Objective: Acrylonitrile (a chemical pollutant) has been reported to induce harmful effects in humans. Therefore, this study was designed to evaluate the protective effects of hesperidin, a natural bioflavonoid, against the toxicity induced by acrylonitrile (AN) in rats. Material&Methods: This study includes determination of serum total scavenger capacity “TSC”, liver enzymes (aspartate transaminase “ASAT”, alanine transaminase “ALAT” and alkaline phosphatase “ALP”), total proteins, albumin, glucose, creatinine, urea and lipid profile. Moreover, liver and kidney homogenate glutathione content “GSH”, catalase, superoxide dismutase “SOD”, glutathione peroxidase “GPx”, malondialdehyde “MDA” and some minerals were estimated.
Results: revealed that administration of AN (orally 50mg/ kg b.wt.) induced alterations in TSC level as well as liver, kidney and lipid profiles. In addition, a decrease in GSH-content and catalase, SOD and GPx activities was observed with an increase in MDA levels in both liver and kidney. There was disturbance in certain minerals such as Cu, Zn, Fe, Se, Ca, Mg and Mn. Conclusion: particularly, Hesperidin administration (orally 200 mg/kg b.wt.) ameliorates the oxidative stress induced by AN, consistent with the reported antioxidant activity of hesperidin.
 
Keywords
Acrylonitrile; Hesperidin; antioxidants and rats
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