Influence of Toltrazuril on Disposition Kinetic and Bioavailability of Thiamphenicol in Broilers | ||
| Journal of Current Veterinary Research | ||
| Article 10, Volume 3, Issue 1, April 2021, Pages 86-92 PDF (323.35 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcvr.2021.160256 | ||
| Authors | ||
| Taha Attia1; Saber El-Hanbaly1; eman elhoseiny* 2 | ||
| 1Department of Pharmacology, Faculty of Veterinary Medicine, University of Sadat City. | ||
| 2pharmacology department, faculty of veterinary medicine, universty of sadat city | ||
| Abstract | ||
| The Effect of toltrazuril on the disposition kinetics and bioavailability of thiamphenicol following a single intravenous (IV) and oral administrations in broiler chickens at a dose of 30 mg/kg body weight was investigated. The serum thiamphenicol concentration was detected by high performance liquid chromatography. After IV injection, thiamphenicol serum concentration was best to be described by a two-compartment open model. Toltrazuril pretreatment was resulted in a significance increase in Vdss and Cltot (3.51±0.1and 0.38±0.005 L/kg, respectively) of thiamphenicol compared with thiamphenicol administered alone (2.31±0.1 and 0.31±0.006L /kg, respectively).The elimination half-life and the mean residence time of thiamphenicol were 4.58±0.2 and 2.44±0.1, 5.72±0.2 and 2.25±0.1h., in control and toltrazuril pretreated chickens, respectively. Following oral dosing, the maximum serum concentration was 14.58±0.1 and 11.88±0.04 μg/ml reached at 3.64±0.01 and 3.56±0.01h, in control and toltrazuril pretreated chickens, respectively. Oral bioavailability was found to be 117.79± 1.2 and114.85 ±0 .7 % in control and toltrazuril pretreated chickens, respectively. It was concluded that the pretreatment of toltrazuril with thiamphenicol in broilers altered the pharmacokinetic profile of thiamphenicol. | ||
| Keywords | ||
| Toltrazuril; Thiamphenicol - Broilers-disposition kinetics | ||
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