Levels of five biochemical parameters in asthmatic patient’s blood as markers for bronchial asthma induced by the house-dust mite allergy | ||
| Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology | ||
| Article 4, Volume 4, Issue 1, December 2012, Pages 25-30 PDF (165.95 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsc.2012.16122 | ||
| Authors | ||
| Yousry Z. A. El-Zohery1; Mohamed A. Kenawy2; Ashraf A. Awad2; Nadia Helmi2; Akila M. El-Shafei2; Yousrya M. Abdel-Hamid3 | ||
| 1Department of Hematology and Immunology, Faculty of Medicine, Al-Azhar University | ||
| 2Department of Entomology, Faculty of Science, Ain Shams University, Cairo | ||
| 3Research Institute of Medical Entomology, The General Organization for Institutes and Teaching Hospitals, Ministry of Health, Dokki, Giza, A.R. Egypt. | ||
| Abstract | ||
| The study examines the validity of five biochemical parameters as indicators for the activity and intensity of asthma induced by the house-dust mite allergy. Blood samples of forty children (28 males and 12 females of 0.5 - 15 years old) suffering from moderate (31) and severe (9) attack of asthma and of 10 non asthmatic children (6 males and 4 females of similar age range) were examined. Levels of histamine, total serum IgE, SIgE, ECP and AEC were significantly higher in the asthmatic- than in the normal cases. Furthermore, severe asthmatic cases had significantly higher levels as compared to the moderate ones, i.e., mean values for [Moderate < Severe] > Check cases. As a conclusion, the elevated levels of such biochemical parameters are associated with HDM asthmatics and are correlated with the severity of asthma attacks. Thus these five parameters may be considered as good markers for HDM asthma activity and severity. | ||
| Keywords | ||
| HDM allergy; histamine; Immunoglobulin E; Eosinophil cationic protein; Absolute eosinophil count; Asthmatic patients. Cairo; Egypt | ||
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