Attia, N., Agha, A., abas, S., el shimi, O. (2021). The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.. test, 38(1), 334-343. doi: 10.21608/bmfj.2021.60711.1376
Noha Moustafa Attia; Adel M Agha; safaa ebrahim abas; ola samir el shimi. "The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.". test, 38, 1, 2021, 334-343. doi: 10.21608/bmfj.2021.60711.1376
Attia, N., Agha, A., abas, S., el shimi, O. (2021). 'The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.', test, 38(1), pp. 334-343. doi: 10.21608/bmfj.2021.60711.1376
Attia, N., Agha, A., abas, S., el shimi, O. The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.. test, 2021; 38(1): 334-343. doi: 10.21608/bmfj.2021.60711.1376

The Relation between Serum Progranulin and Platelet Count in Immune Thrombocytopenia Patients.

Benha Medical Journal
Article 27, Volume 38, Issue 1, April 2021, Pages 334-343    PDF (864.68 K)
Document Type: Original Article
DOI: 10.21608/bmfj.2021.60711.1376
Authors
Noha Moustafa Attia* 1; Adel M Agha2; safaa ebrahim abas3; ola samir el shimi4
1medical university
2clinical & chemical pathology dep., Faculty of Medicine, Benha university , Egypt
3clinical & chemical pathology department,faculty of medicine , Benha university , Egypt.
4clinical & chemical pathology department,faculty of medicine, Benha university, Egypt.
Abstract
Background: Immune thrombocytopenia (ITP) is an autoimmune disease with excessive platelet destruction and reduced platelet production. Progranulin (PGRN) has a protective effect against autoimmune diseases by competitive binding tumor necrosis factor-α receptors. Thus, we assessed the serum progranulin level in relation to platelet count in ITP patients, pre-and post-induction of corticosteroid therapy.
Methods: A case – control study was conducted on 30 ITP patients and 30 apparently healthy subjects serving as acontrol group. Platelet count and serum progranulin levels were measured in newly diagnosed ITP patients before and 3−7 days after starting corticosteroid treatment.
Results: The mean serum level of PGRN was significantly higher in ITP patients pre-treatment compared to healthy control subjects (P
Keywords
Progranulin; Immune Thrombocytopenia; Biomarker; Protective
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