Auda, S., Ahmed, M., Abd El-Rasoul, S. (2011). EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES. test, 20(1), 1-8. doi: 10.21608/zjps.2011.161988
Sayed Auda; Mahmoud Ahmed; S. Abd El-Rasoul. "EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES". test, 20, 1, 2011, 1-8. doi: 10.21608/zjps.2011.161988
Auda, S., Ahmed, M., Abd El-Rasoul, S. (2011). 'EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES', test, 20(1), pp. 1-8. doi: 10.21608/zjps.2011.161988
Auda, S., Ahmed, M., Abd El-Rasoul, S. EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES. test, 2011; 20(1): 1-8. doi: 10.21608/zjps.2011.161988

EFFECT OF DIFFERENT NON IONIC SURFACTANTS ON THE IN-VITRO RELEASE RATE OF A NON STEROIDAL ANTI-INFLAMMATORY DRUG FROM SOME LIPOPHILIC SUPPOSITORY BASES

Zagazig Journal of Pharmaceutical Sciences
Article 1, Volume 20, Issue 1, June 2011, Pages 1-8    PDF (1.93 M)
Document Type: Original Article
DOI: 10.21608/zjps.2011.161988
Authors
Sayed Auda* 1; Mahmoud Ahmed2; S. Abd El-Rasoul1
1Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt.
2Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Al-Azhar University, Assiut branch, Assiut, Egypt
Abstract
Formulation of tolmetin sodium suppositories was carried out using different lipophilic bases as Novatta, suppocir NA10. suppocir W35, suppocir AM, Witepsol E75 and Witepsol H15. The in vitro release study of 200 mg tolmetin sodium suppository from these bases was performed in Sorensen's phosphate buffer (pH 7.4) at 37 °C. The results obtained revealed that Novatta and suppocir W35 gave the highest release rate followed by suppocir NA10, Witesol E75, Witepsol H15 and Suppocir AM respectively. The effect of type and concentrations of different non ionic surfactants as polysorbate 20, polysorbate 60, polysorbate 80, Brij 35, Brij 58, Myrj 53 and Myrj 59 on the drug release from suppocir AM was investigated.
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