EFFECT OF YOGHURT PILLARED WITH PROPOLIS ON HYPERGLYCEMIC RATS | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 14, Volume 49, Issue 1, October 2012, Pages 691-704 PDF (252.99 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2012.16208 | ||
| Authors | ||
| Hassan M. Bukhari1; Abdelghany H. Abdelghany2; Ibrahim Saad Nada3; Eslam A. Header4 | ||
| 1Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm al Qura University Makkah, Saudi Arabia | ||
| 2Department of Anatomy and Embryology Faculty of Medicine, Alexandria University, Egypt | ||
| 3Laboratory Department, Faculty of Applied Medical Sciences, Umm al Qura University, Makkah, Saudi Arabia | ||
| 4Nutrition and Food Science Department, Faculty of Home Economics Minufiya University, Egypt. | ||
| Abstract | ||
| Dietary supplementation of yoghurt with plants rich in antioxidants such as propolis which is an adhesive resinous material collected by honey bees is recently recommended. This study aimed at investigating the protective effect against the hyperglycemia and hyperlipidemia. The study showed that yoghurt with propolis had a hypoglycemic effect together with reduction of the serum levels of cholesterol, low density and very low density lipoproteins with elevation of high density lipoproteins. The atherosclerosis indices were affected with reduction of low density lipoproteins-cholesterol/high density lipoproteins-cholesterol and elevation of the high density lipoprotein-cholesterol/total cholesterol. This was attributed to the reduction of glucose absorption and inhibition of α-glucosidase together with the antioxidant activity with regain of the pancreatic β-cell function. The hypolipidemic effect and consequently protective effect against atherosclerosis was attributed to the binding, breakdown and reduction of absorption of cholesterol together with the antioxidant activity of both yoghurt and propolis. Down regulation of the expression of the angiogenic gene factors which have a role in the pathogenesis of atherosclerosis may play a role. Thus, this dietary supplementation may be manufactured and used for its value in reducing hyperglycemia and hyperlipidemia in cases of diabetes mellitus. | ||
| Keywords | ||
| yoghurt; Propolis; Diabetes mellitus; Atherosclerosis; hyperglycemia; hyperlipedemia; Cholesterol; lipoproteins antioxidants | ||
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