INTRASTROMAL INJECTION VERSUS TOPICAL DROPS OF VORICONAZOLE FOR RESISTANT FUNGAL CORNEAL ULCER | ||
| Egyptian Journal of Clinical Ophthalmology | ||
| Article 3, Volume 3, Issue 1, June 2020, Pages 19-24 PDF (434.28 K) | ||
| Document Type: Original articles: include clinical trials, interventional research, Basic researches and clinically relevant laboratory investigations | ||
| DOI: 10.21608/ejco.2020.162966 | ||
| Authors | ||
| Mahmoud, H.; Abd El-Badie, M.; Ahmed, I. | ||
| Ophthalmology dept., Faculty of Medicine, Al-Azhar Univ., Assiut, Egypt | ||
| Abstract | ||
| Aim: To evaluate safety and efficacy of intrastromal injection of voriconazole in treating resistant fungal corneal ulcer. Patients and methods: A prospective, randomized study performed on patients with resistant fungal ulcer. Patients were randomly distributed into two groups: Group (A) included 10 eyes of patient treated with intrastromal injection(s) of voriconazole (50 μg/0.1 ml) and group (B) included 10 eyes treated with topical voriconazole eye drops 1%. Primary outcome measure was healing of the fungal ulcer. Secondary outcome measures included duration of healingin healed cases, any reported complication and the visual outcome. Results: Healing of fungal ulcer was higher in group A (80%) than in group B (30%) and the difference was statistically significant. The range of duration of healing in group A was less than that in group B. Ocular trauma (especially with plant matter) was considered as important risk factor. Conclusion: Voriconazole eye drops might be considered as effective treatment for resistant fungal ulcer. Delivering voriconazole by intrastromal injection could raise the healing rate and decreasing the resolution period with no significant complications. | ||
| Keywords | ||
| Intrastromal injection; Fungal ulcer; Topical; Voriconazole | ||
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