Protective effects of sulpiride treatment on kidney functions of female albino rats exposed to noise stress. | ||
| The Egyptian Journal of Hospital Medicine | ||
| Article 3, Volume 44, Issue 1, July 2011, Pages 284-294 PDF (491.2 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ejhm.2011.16408 | ||
| Authors | ||
| Eman G .Helal1; Fatma Eid2; Neama M. Taha.3 | ||
| 1Zoology Department ,Faculty of Science,Al-Azhar University. ( Physiology) | ||
| 2Zoology Department ,Faculty of Science,Al-Azhar University. ( Histology) | ||
| 3Zoology Department ,Faculty of Science,Al-Azhar University | ||
| Abstract | ||
| Background: Noise is the most stressful factor for experimental animals. So these studies aim to clarify its effect on some physiological and histological parameters. Material and methods: 36 Female rats were divided into four groups (6/each):1-control, 2-treated with sulpiride drug,3- noise exposure (90db/3h per day for 30days), 4-noise + drug Results: drug recorded no significant change in all the studied parameters. Noise stress recorded a significant increase in creatinine, total lipids, TG, Cholesterol, HDL-C, LDL-C and no significant changes in urea, uric acide. It has been detected that sulpiride drug ameliorated most of these parameters.Concerning the histological and histochemical studies sulpiride treatment showed no detectable changes in the kidney tissue with exception of increased lymphocytes. Exposure to noise showed many dystrophic changes in the kidney tissue, but drug treatment improved all the previous changes and this indicates the protective effect of sulpiride against noise exposure. Conclusion: It is useful to use sulpiride drug in people who exposed to noise stress. | ||
| Keywords | ||
| Noise; Sulpiride drug; albino rats; physiological parameters; Histopathalogy and histochemistery | ||
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