Hamama, W., Gouda, M., Kamal El-din, H., Zoorob, H. (2021). Synthesis of some heterocyclic of expected bioactivity via reactions of thiazine derivatives: Thesis Abstract. test, 5(1.1), 44-44. doi: 10.21608/jcbr.2021.60773.1158
Wafaa Salama Hamama; Mostafa Gouda; Hadwah A. Kamal El-din; Hanafi Zoorob. "Synthesis of some heterocyclic of expected bioactivity via reactions of thiazine derivatives: Thesis Abstract". test, 5, 1.1, 2021, 44-44. doi: 10.21608/jcbr.2021.60773.1158
Hamama, W., Gouda, M., Kamal El-din, H., Zoorob, H. (2021). 'Synthesis of some heterocyclic of expected bioactivity via reactions of thiazine derivatives: Thesis Abstract', test, 5(1.1), pp. 44-44. doi: 10.21608/jcbr.2021.60773.1158
Hamama, W., Gouda, M., Kamal El-din, H., Zoorob, H. Synthesis of some heterocyclic of expected bioactivity via reactions of thiazine derivatives: Thesis Abstract. test, 2021; 5(1.1): 44-44. doi: 10.21608/jcbr.2021.60773.1158

Synthesis of some heterocyclic of expected bioactivity via reactions of thiazine derivatives: Thesis Abstract

Egyptian Journal of Cancer and Biomedical Research
Article 46, Volume 5, Issue 1.1, May 2021, Pages 44-44    PDF (175.85 K)
Document Type: Essay Abstract
DOI: 10.21608/jcbr.2021.60773.1158
Authors
Wafaa Salama Hamama1; Mostafa Gouda2; Hadwah A. Kamal El-din* 3; Hanafi Zoorob2
1Chemistry Department, Faculty of Science, Mansoura University, Mansoura, Egypt.
2Department of Chemistry, Faculty of Science, Mansoura University, El-Gomhoria Street, Mansoura, Egypt
3Chemistry Department, Faculty of Science, Mansoura University, El-Gomhoria Street, ET-35516 Mansoura, Egypt.
Abstract
Thesis Abstract:
2-acetylphenothiazine plays an important role in organic chemistry. The behavior of 2-acetylphenothiazine towards various reagents was carried out. Thus, the aim of the present work is to design and synthesize some of heterocyclic nuclei through the reaction of phenothiazine derivatives as scaffold moiety with different reagents. α,β-Unsaturated ketones containing phenothiazine moiety 4, 5, 7 were synthesized by condensation of 2-acetylphenothiazine with different aryl aldehydes 2, 3, and (DMFDMA). Pyrazole skeletons were also synthesized by 1,3-dipolar cycloaddition reactions of α,β-unsaturated ketones with different nucleophilic reagents. Formylpyrazole derivative 36 was synthesized through the Vilsmeier-Haack reaction of phenylhydrazone 35b. Azines derivatives of phenothiazines were synthetically constructed from one-pot multicomponent reactions of 1-(4a, 10a-dihydro-10H-phenothiazine-2-yl) ethan-1-one with various reagents. Newly synthesized compounds were screened as antioxidant agents. The sequence of these reactions that adopted for the synthesis of the designed compounds in this thesis is summarized into two sections. Furthermore, studying of the biological activity of the newly synthesized compounds as antioxidants properties were performed.
Keywords
Anti-oxidant; 2-acetylphenothiazine; Aminonicotinonitriles; Pyrazoles; Pyridine
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