Lactobacillus acidophilus and bifidobacterium bifidum reduce chronic HCV progression: Thesis Abstract | ||
| Egyptian Journal of Cancer and Biomedical Research | ||
| Article 35, Volume 5, Issue 1.1, May 2021, Pages 33-33 PDF (183.42 K) | ||
| Document Type: Essay Abstract | ||
| DOI: 10.21608/jcbr.2021.63823.1180 | ||
| Authors | ||
| Maii Nabieh* 1; Mohamed Labib Salem2; Nanis Allam3; Hassan EL-Batae4 | ||
| 1Microbiology Department, Faculty Science, Tanta university, Tanta, Egypt | ||
| 2Immunology and Biotechnology Division, Department of Zoology, Faculty of Science, Tanta University, Egypt | ||
| 3Microbiology Department, Faculty of Science, Tanta University, Tanta, Egypt | ||
| 4Professor of the Liver, Gastrointestinal Tract and Infectious Diseases, Department of Tropical Medicine, Kafr El-Shiekh University, Egypt | ||
| Abstract | ||
| Thesis Abstract Background: Hepatitis C virus (HCV) is a major leading cause of pathogenesis of liver disease which was treated with IFN-based therapy and recently with Sovaldi®. There is a challenge to explore new drugs. Probiotics are the most common natural therapeutic that can ameliorate liver dysfunction. Aim: study the antiviral and antibacterial responses of the probiotics in patients with chronic (HCV). Materials and Methods: patients were treated with IFN/ribavirin, or both IFN and probiotics capsule that was containing L. acidophilus and Bifidobacterium spp. and administered as one capsule per day for a month. Blood and urine samples were collected before and after treatment strategies and were processed for quantitative determination of HCV PCR assay, identification of bacteria by VITEK2 system and 16S r RNA gene sequencing, estimation of probiotics antibacterial activity, as well as counts of leukocytes and CD3+ T cells and CD56+ natural killer cells. Results: Treatment of patients with L. acidophilus and Bifidobacteria spp. enhanced the responses of the patients to IFN-α and ribavirin treatment, as shown by the viral titter of HCV PCR assay that clarified the antiviral activity and also the antibacterial activity against the most common bacterial infections in patients with chronic HCV. Additionally, it increased the numbers of CD3+ and CD56+, Conclusions: Treatment with probiotics before IFN-α and ribavirin therapy can act as a supportive supplement with antiviral, positive immune response and antibacterial activities | ||
| Keywords | ||
| Bifidobacterium befidum; Lactobacillus acidophilus; HCV infection, Probiotics | ||
|
Statistics Article View: 565 PDF Download: 187 |
||
