The Antibacterial Activity Of Bee Venom On Selected Pathogenic Bacteria | ||
| Egyptian Academic Journal of Biological Sciences, G. Microbiology | ||
| Article 8, Volume 7, Issue 1, December 2015, Pages 69-75 PDF (419.36 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsg.2015.16487 | ||
| Authors | ||
| Amany Z. Salem1; El-Sayed H. Bedair2; Wael R. Hablas3; Abir A. Elfiky4; Basma I. Hussein5 | ||
| 1Entomology Department, Faculty of Science, Ain Shams University | ||
| 2Beekeeping, Agriculture Research Center, Giza | ||
| 3Clinical pathology Department, Faculty of medicine Al-Azhar University | ||
| 4Director of ANDI center of excellence in antivenom research, Vacsera, Egypt | ||
| 5Faculty of science Ain shams university | ||
| Abstract | ||
| Honey bee venom of Apis mellifera carnica with LD50 equal to 290µg/mouse, was analyzed by HPLC (high performance liquid chromatography) to perform its activity and found that it contains the most important active compounds which are Melittin (52.1%), Phospholipase A2(11.9%), and Apamin (2.3%) then tested against selected pathogenic bacteria invitro. The selected bacteria were Methicillin resistant Staphylococcus aureus (MRSA), Proteus sp., E.coli ,Salmonella sp., The results showed that bee venom has high significant effect on Gram positive bacteria (MRSA), and from moderate to low significance on gram negative bacteria (Proteus sp., E.coli , Salmonella sp.) therefore Bee venom could be a promising alternative antibiotic | ||
| Keywords | ||
| Bee venom; Pathogenic bacteria; HPLC; MRSA; Antibacterial activity | ||
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