Synergistic Effects of Honeys and Commonly Used Antibiotics on Gram Positive Bacteria | ||
| Egyptian Academic Journal of Biological Sciences, G. Microbiology | ||
| Article 12, Volume 7, Issue 1, December 2015, Pages 101-109 PDF (267.89 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/eajbsg.2015.16491 | ||
| Authors | ||
| Masoud E. A.; Alqurashi A. M.; Alamin A. A. | ||
| Department of Applied Medical Sciences, Community College, Najran University, Saudi Arabia | ||
| Abstract | ||
| This study aimed to investigate the growth inhibitory effect of sidr and sommor honeys and to evaluate the synergistic effects of various honey concentrations and five antibiotics on gram-positive bacteria in vitro using agar well diffusion and disk diffusion techniques. This is the first time for studying the antibacterial activity and synergistic effect of sommor honey against bacteria. The results indicated that sidr and sommor honeys had antibacterial activity against the clinical isolates and reference strains of S. aureus and Strept. pyogenes. The reference strains were more susceptible to sidr honey than sommor honey while the clinical isolates were more susceptible to sommor honey than sidr honey. Increasing honey concentrations either alone or in combination with antibiotics was significantly increased (P<0.05) the growth inhibition of the tested bacteria. The synergistic effects of honeys with antibiotics were significantly (P<0.05) different among the tested gram-positive bacteria. The highest synergistic effect was observed against Strept. pyogenes clinical isolate when sidr and sommor honeys combined with ofloxacin, pipracillin, amoxicillin + clavulanic acid and sulphamethoxazole + trimethoprim. It can be concluded that sidr and sommor honeys improved the antibiotic activity and presented a new avenue for treatment of gram-positive bacterial infections. | ||
| Keywords | ||
| Honey; antibiotics; Gram positive bacteria; Synergistic Effects. Antibacterial Activity | ||
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